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首页> 外文期刊>Environmental toxicology and chemistry >Pulp And Paper Mill Effluent Treatments Have Differential Endocrine-disrupting Effects On Rainbow Trout
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Pulp And Paper Mill Effluent Treatments Have Differential Endocrine-disrupting Effects On Rainbow Trout

机译：制浆造纸厂废水处理对虹鳟鱼的内分泌干扰作用不同

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Endocrine disruption (ED) effects due to pulp and paper mill effluents extracts involving different industrial procedures and effluent treatments (nontreated, primary, and secondary treated) were evaluated using immature triploid rainbow trout in a pulse-exposure toxicity experiment. The protocol involved the use of intraperitoneal injection of mill extracts (solid-phase extraction [SPE]) corrected for individual fish weight and included several laboratory standards (steroidal hormones and phytosterols). Biological endpoints at two different levels of biological organization were analyzed (molecular and individual organism). Results indicated that nonsignificant changes were observed in the individual physiological indices represented by condition factor, liver somatic index, and gonad somatic index during the experiment. Significant induction of liver ethoxyresorufin-O-deethylase activity was observed between different effluent treatments and experimental controls. Significant endocrine-disrupting effects at the reproductive level were observed in all effluent treatments involving significant increments in plasma vitellogenin (VTG) levels. Fish exposed to untreated effluent extracts had significantly higher VTG levels compared to fish exposed to primary and secondary treatment effluent extracts, indicating a decrease of the estrogenic effect due to the effluent treatment. The present study has shown that for the Chilean pulp and paper mill SPE extracts evaluated, an endocrine disruption effect was induced in immature triploid rainbow, reaffirming the significant estrogenic effects demonstrated previously in laboratory and field experiments.
机译：在脉冲暴露毒性实验中，使用未成熟的三倍体虹鳟评估了由于纸浆和造纸厂废水提取物涉及不同的工业程序和废水处理（未处理，初级和二级处理）引起的内分泌干扰（ED）效应。该方案涉及腹膜内注射经过碾磨的提取物（固相提取物[SPE]），这些提取物已根据鱼的个体体重进行了校正，并包括了几种实验室标准品（甾体激素和植物甾醇）。分析了两个不同生物组织水平（分子和单个生物体）的生物学终点。结果表明，在实验过程中，由条件因子，肝体细胞指数和性腺体细胞指数代表的各项生理指标均未见明显变化。在不同的出水处理和实验对照之间观察到肝乙氧基间苯二酚-O-脱乙基酶活性的显着诱导。在涉及血浆卵黄蛋白原（VTG）水平显着增加的所有污水处理中，均观察到了生殖水平上的显着干扰内分泌的作用。暴露于未经处理的污水提取物中的鱼比暴露于一级和二级处理的污水提取物中的鱼具有更高的VTG水平，这表明由于污水处理导致的雌激素作用降低。本研究表明，对于智利纸浆和造纸厂的SPE提取物，未成熟的三倍体彩虹诱导了内分泌干扰作用，重申了先前在实验室和现场实验中证明的显着雌激素作用。

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