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首页> 外文期刊>Environmental toxicology and chemistry >Stage-dependent Teratogenic And Lethal Effects Exerted By Ultraviolet B Radiation On Rhinella (bufo) Arenarum Embryos
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Stage-dependent Teratogenic And Lethal Effects Exerted By Ultraviolet B Radiation On Rhinella (bufo) Arenarum Embryos

机译：紫外线B辐射对莱茵兰（bulf）阿雷纳姆胚芽的阶段依赖性致畸和致命作用。

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The adverse effects of ultraviolet B radiation from 547.2 to 30,096 J/m~2 on morphogenesis, cell differentiation, and lethality of amphibian embryos at six developmental stages were evaluated from 24 up to 168 h postexposure. The ultraviolet B radiation lethal dose 10, 50, and 90 values were obtained for all developmental stages evaluated. The lethal dose 50 values, considered as the dose causing lethality in the 50% of the organisms exposed, in J/m~2 at 168 h postexposure, ranged from 2,307 to 18,930; gill circulation and blastula were the most susceptible and resistant stages, respectively. Ultraviolet B radiation caused malformations in all developmental stages but was significantly more teratogenic at the gill circulation and complete operculum stages. Moreover, at the gill circulation stage, even the lowest dose (547.2 J/m~2) resulted in malformations to 100% of embryos. The most common malformations were persistent yolk plug, bifid spine, reduced body size, delayed development, asymmetry, microcephaly and anencephaly, tail and body flexures toward the irradiated side, agenesia or partial gill development, abnormal pigment distribution, and hypermotility. The stage-dependent susceptibility to ultraviolet B radiation during amphibian embryo-genesis could be explained in the framework of evoecotoxicology, considering ontogenic features as biomarkers of environmental signatures of living forms ancestors during the evolutionary process. The stage-dependent susceptibility to ultraviolet B radiation on Rhinella (Bufo) arenarum embryos for both lethal and teratogenic effects could contribute to a better understanding of the role of the increased ultraviolet B radiation on worldwide amphibian populations decline.
机译：从暴露后24小时到168小时，评估了547.2至30,096 J / m〜2的紫外线B辐射对六个发育阶段两栖胚胎的形态发生，细胞分化和致死性的不利影响。对于评估的所有发育阶段，获得紫外线B致死剂量10、50和90的值。致死剂量50值（被认为是造成50％暴露生物致死率的剂量）在暴露后168小时以J / m〜2为单位，范围为2,307至18,930； circulation循环和囊胚分别是最易感和抵抗力最高的阶段。紫外线B辐射在所有发育阶段均引起畸形，但在g循环和整个盖阶段明显更具致畸性。此外，在the循环阶段，即使最低剂量（547.2 J / m〜2）也会导致100％胚胎畸形。最常见的畸形是持续的卵黄塞，双裂脊柱，体型减小，发育迟缓，不对称，小头畸形和无脑，尾巴和身体向受照侧弯曲，发育不全或部分g发育，色素分布异常和运动过度。两栖动物胚胎发生过程中对紫外线B辐射的阶段依赖性敏感性可以在病毒生态毒理学的框架内进行解释，考虑到在进化过程中作为生命形式祖先的环境特征的生物标志物的生物特征。阶段性对莱茵兰（Bufo）竞技场胚胎的紫外线B辐射的致死性和致畸作用的敏感性可能有助于更好地了解增加的紫外线B辐射对全球两栖动物种群数量下降的作用。

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