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首页> 外文期刊>Environmental toxicology and chemistry >SUBLETHAL EFFECTS OF METHYLMERCURY ON FECAL METABOLITES OF TESTOSTERONE, ESTRADIOL, AND CORTICOSTERONE IN CAPTIVE JUVENILE WHITE IBISES (EUDOCIMUS ALBUS)
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SUBLETHAL EFFECTS OF METHYLMERCURY ON FECAL METABOLITES OF TESTOSTERONE, ESTRADIOL, AND CORTICOSTERONE IN CAPTIVE JUVENILE WHITE IBISES (EUDOCIMUS ALBUS)

机译：甲基汞对幼稚白鼬（Eucodimus albus）睾丸甾酮，雌二醇和生育固醇的粪便代谢产物的影响

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摘要

Methylmercury (MeHg) is a globally distributed neurotoxin, endocrine disruptor, and teratogen, and its effects on birds are poorly understood, especially within an environmentally relevant exposure range. In an effort to understand the potential causal relationship between MeHg exposure and endocrine development, we established four dietary exposure groups (0 [control], 0.05, 0.1, and 0.3 mg/kg wet wt/d of MeHg) of postfledging white ibises (Eudocimus alhus) in a divided, free-flight aviary that spanned the estimated range of environmental exposure for this species. Fecal samples were collected from individually identified ibises over six months in 2005 and processed for hormone evaluation. Significant sex-related differences in fecal estradiol concentrations, though unpredicted in direction, suggest that this steroid could be related to juvenile development in this species. Using repeated-measures general linear models, we tested a set of candidate models to explain variation in endocrine expression. We found that MeHg exposure led to significant differences in fecal estradiol concentrations between the control and medium-dose groups, whereas differences in fecal corticosterone concentrations were observed between the control and both the low- and high-dose groups. These results suggest highly nonlinear dose-response patterns for MeHg. Many endocrine-disrupting contaminants are theorized to affect multiple endpoints in a nonlinear manner, making results difficult to interpret using a traditional toxicological approach. The evidence presented here suggests that endocrine effects of MeHg exposure could behave similarly.
机译：甲基汞（MeHg）是一种遍布全球的神经毒素，内分泌干扰物和致畸剂，人们对它对鸟类的影响了解甚少，尤其是在与环境有关的接触范围内。为了理解MeHg暴露与内分泌发育之间的潜在因果关系，我们建立了四个宜居后朱鹭（Eudocimus）的饮食暴露组（0 [对照组]，0.05、0.1和0.3 mg / kg湿重/ d MeHg）。在一个分散的，自由飞行的鸟类舍中，该鸟类跨越了该物种的环境暴露估计范围。在2005年的六个月中，从单独鉴定的朱鹭中收集粪便样本，并进行处理以进行激素评估。粪中雌二醇浓度的显着性别相关差异尽管方向无法预测，但表明该类固醇可能与该物种的少年发育有关。使用重复测量的一般线性模型，我们测试了一组候选模型来解释内分泌表达的变化。我们发现MeHg暴露导致对照组和中剂量组之间的粪便雌二醇浓度存在显着差异，而对照组与低剂量和高剂量组之间的粪便皮质酮浓度存在差异。这些结果表明MeHg的高度非线性剂量反应模式。从理论上讲，许多破坏内分泌的污染物会以非线性方式影响多个终点，从而使得使用传统毒理学方法难以解释结果。此处提供的证据表明，甲基汞暴露的内分泌作用可能具有相似的行为。

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  • 来源
    《Environmental toxicology and chemistry》 |2009年第5期|982-989|共8页
  • 作者

    Evan M. Adams; Peter C. Frederick; Iske L.V. Larkin; Louis J. Guillette Jr.;

  • 作者单位

    Department of Wildlife Ecology and Conservation, P.O. Box 1 10430, University of Florida, Gainesville, Florida 32611, USA;

    Department of Wildlife Ecology and Conservation, P.O. Box 1 10430, University of Florida, Gainesville, Florida 32611, USA;

    Department of Large Animal Clinical Sciences, P.O. Box 100136, University of Florida, Gainesville, Florida 32610, USA;

    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    methylmercury; white ibis; endocrine disruption; fecal metabolites;

    机译：甲基汞白宜必思酒店内分泌干​​扰粪便代谢物;

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