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首页> 外文期刊>Environmental toxicology and chemistry >IDENTIFICATION AND EVALUATION OF PYRETHROID INSECTICIDE MIXTURES IN URBAN SEDIMENTS
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IDENTIFICATION AND EVALUATION OF PYRETHROID INSECTICIDE MIXTURES IN URBAN SEDIMENTS

机译：城市沉积物中拟除虫菊酯类农药混合物的鉴定与评价

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摘要

Organochlorine, organophosphorous, and pyrethroid insecticides frequently have been detected together as mixtures in stream sediments. To simplify mixture analyses, additive toxic responses usually are assumed but rarely are confirmed, especially for compounds with similar modes of action. The first objective of the present study was to screen a database of 24 different pesticides and 94 urban-stream sediment samples collected throughout central and northern California (USA) to identify compounds and partial mixtures that dominated sample toxicity to Hyalella azteca. Pyrethroids and chlorpyrifos were the most toxicologically relevant compounds in terms of detection frequency, contribution to overall sample toxicity, and co-occurrence in the most common mixture patterns. Organochlorine insecticides were the least toxicologically relevant compounds, with only a small percentage of samples exceeding predefined screening values. The second objective was to confirm that mixtures of type I and type II pyrethroids display additive responses. Ten-day sediment toxicity tests of binary pesticide mixtures were conducted using H. azteca as the test organism. Observed dose-response curves were compared to those predicted from concentration-addition and independent-action models. Model deviation ratios (MDRs) were calculated at the median effect level to quantify the magnitudes of deviation between observed and predicted curves. Whereas the concentration-addition model adequately predicted toxicity for all the pyrethroid mixtures (MDRs within a factor of two), dose-response values deviated from additivity enough to warrant further investigation.
机译：有机氯，有机磷和拟除虫菊酯类杀虫剂经常以混合物形式在河流沉积物中被发现。为了简化混合物分析，通常假设会发生加成毒性反应，但很少被证实，特别是对于具有相似作用方式的化合物。本研究的第一个目标是筛选一个数据库，该数据库包含从加利福尼亚中部和北部（美国）收集的24种不同农药和94种城市河流沉积物样品的数据，以鉴定出对样品中的透明质酸有毒的化合物和部分混合物。就检测频率，对总体样品毒性的贡献以及在最常见的混合物模式中同时出现而言，拟除虫菊酯和毒死rif是与毒理学最相关的化合物。有机氯杀虫剂是毒理学上相关性最低的化合物，只有一小部分样品超过了预定的筛选值。第二个目的是确认I型和II型拟除虫菊酯的混合物显示出加性反应。使用阿兹台克人作为测试生物对二元农药混合物进行为期十天的沉积物毒性测试。将观察到的剂量反应曲线与从浓度加和独立作用模型预测的剂量反应曲线进行比较。在中位效应水平上计算模型偏差比（MDR），以量化观察曲线和预测曲线之间的偏差幅度。尽管浓度加成模型可以充分预测所有拟除虫菊酯混合物的毒性（MDR在2倍以内），但剂量反应值与可加性的偏差足以让我们进一步研究。

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  • 来源
    《Environmental toxicology and chemistry》 |2009年第8期|1687-1695|共9页
  • 作者

    Andrew J. Trimble; Donald P. Weston; Jason B. Belden; Michael J. Lydy;

  • 作者单位

    Fisheries and Illinois Aquaculture Center and Department of Zoology, Southern Illinois University, Carbondale, Illinois 62901-4306, USA;

    Department of Integrative Biology, University of California, 3060 Valley Life Sciences Building, Berkeley, California 94720-3140, USA;

    Department of Zoology, Oklahoma State University, Stillwater, Oklahoma 74078-0002, USA;

    Fisheries and Illinois Aquaculture Center and Department of Zoology, Southern Illinois University, Carbondale, Illinois 62901-4306, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    pyrethroid; organochlorine; organophosphorus; mixture; sediment;

    机译：拟除虫菊酯有机氯有机磷混合物;沉淀;

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