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首页> 外文期刊>Environmental toxicology and chemistry >A COMPARISON OF NANOPARTTCLE AND FINE PARTICLE UPTAKE BY DAPHNIA MAGNA
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A COMPARISON OF NANOPARTTCLE AND FINE PARTICLE UPTAKE BY DAPHNIA MAGNA

机译：DAPHNIA MAGNA对纳豆和细颗粒摄取的比较

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摘要

The use of nanoparticles in various applications is steadily on the rise, with use in a range of applications, including printer toner, sunscreen, medical imaging, and enhanced drug delivery. While research on human effects via, for example, inhalation is relatively well developed, the environmental assessment of nanoparticles is in its infancy. In the present study, we assessed the uptake and quantitative accumulation, as well as the depuration, of a model nanoparticle, a 20-nm fluorescent carboxylated polystyrene bead, in the aquatic invertebrate Daphnia magna and compared it to a larger, 1,000-nm particle. Using confocal microscopy, rapid accumulation in the gastrointestinal tract was observed within an hour of exposure to both particle sizes in both adults and neonates. Fluorescence could also be observed in the oil storage droplets, suggesting that both particle sizes have crossed the gut's epithelial barrier. Quantification of fluorescence of both sizes of particles showed that although uptake of the 20-nm particles was lower in terms of mass it was equal to or greater than 1,000-nm particle uptake when expressed as surface area or particle number. Depuration was relatively rapid for the 1,000-nm beads, decreasing by more than 90% over 4 h. In contrast, depuration of the 20-nm beads was less extensive, reaching 40% over 4 h. Transmission electron microscopy confirmed uptake of 1,000-nm beads, but uptake of 20-nm beads was inconclusive since similar-sized inclusions could be observed in control treatments.
机译：纳米粒子在各种应用中的使用稳步增长，并且在一系列应用中使用，包括打印机碳粉，防晒霜，医学成像和增强的药物输送。尽管通过吸入等对人类影响的研究相对完善，但纳米颗粒的环境评估仍处于起步阶段。在本研究中，我们评估了水生无脊椎动物水蚤（Daphnia magna）中模型纳米颗粒（20-nm荧光羧化聚苯乙烯珠）的吸收和定量积累以及净化度，并将其与一个更大的1,000-nm颗粒进行了比较。 。使用共聚焦显微镜，在成年人和新生儿中暴露于两种粒径的一小时内，均观察到了胃肠道中的快速积累。还可以在储油滴中观察到荧光，表明这两种粒径均超过了肠道的上皮屏障。两种尺寸的颗粒的荧光定量显示，尽管20 nm颗粒的吸收质量较低，但以表面积或颗粒数表示，等于或大于1,000 nm颗粒的吸收。 1000 nm珠的净化速度相对较快，在4小时内降低了90％以上。相比之下，对20 nm珠子的净化作用较小，在4小时内达到40％。透射电子显微镜证实吸收了1,000 nm的珠子，但吸收20 nm的珠子尚无定论，因为在对照处理中可以观察到大小相似的夹杂物。

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  • 来源
    《Environmental toxicology and chemistry》 |2009年第10期|2142-2149|共8页
  • 作者

    Philipp Rosenkranz; Qasim Chaudhry; Vicki Stone; Teresa F. Fernandes;

  • 作者单位

    School of Life Sciences, Edinburgh Napier University, 10 Colinton Road, Edinburgh, EH10 5DT Scotland, United Kingdom;

    Central Science Laboratory, Sand Hutton, York YO41 1LZ, United Kingdom;

    School of Life Sciences, Edinburgh Napier University, 10 Colinton Road, Edinburgh, EH10 5DT Scotland, United Kingdom;

    School of Life Sciences, Edinburgh Napier University, 10 Colinton Road, Edinburgh, EH10 5DT Scotland, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    nanoparticles; uptake; depuration; daphnia magna; translocation;

    机译：纳米粒子摄取净化;水蚤易位;

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