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首页> 外文期刊>Environmental toxicology and chemistry >Is Fish Embryo Test (FET) According to OECD 236 Sensible Enough for Delivering Quality Data for Effluent Risk Assessment?
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Is Fish Embryo Test (FET) According to OECD 236 Sensible Enough for Delivering Quality Data for Effluent Risk Assessment?

机译：根据OECD 236的规定，鱼胚胎测试（FET）是否足以提供用于废水风险评估的质量数据？

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Over the past few years, the fish embryo test (FET) has become widely accepted as an animal-friendly protocol for ecotoxicological research. As Organisation for Economic Co-operation and Development (OECD) 236, the FET has been widely applied for simple mixture exposures under the Registration, Evaluation, Authorisation, and Restriction of Chemicals regulation of the European Union; and now its use is spreading worldwide as a supposedly reliable whole-effluent test (i.e., the testing of complex mixture exposures). However, comparative peer-reviewed data regarding the FET's efficiency for whole-effluent tests are virtually nonexistent. The primary objective of the present study was to make the first comparative test between the FET according to OECD 236 and other standard and slightly modified standard fish protocols used worldwide for whole-effluent tests. For that, we used an untreated hospital effluent considered to be highly toxic but disposed of in municipal sewerage. The base methods were OECD 203 (juvenile), US Environmental Protection Agency method 2000.0 (larvae), and OECD 236 (embryo). We also evaluated the addition of 3 virtually costless sublethal metrics (immobility, nonhatching, and pericardial edema) that could enhance the sensitivity of OECD 236. We observed acute toxicity in all 8 methodologies tested, with a clear escalation in sensitivity (larvaejuvenileembryo). Larvae were the most sensitive life stage for whole-effluent tests. The addition of sublethal metrics to OECD 236 enhanced its previous sensitivity in over 30%. Thus we conclude that OECD 236 acts below its potential and that the embryonic stage (as used in the FET) may not be the most sensitive life stage for whole-effluent tests. Environ Toxicol Chem 2018;37:2925-2932. (c) 2018 SETAC
机译：在过去的几年中，鱼胚测试（FET）已被广泛接受为生态毒理学研究的动物友好协议。作为经济合作与发展组织（OECD）236，FET已根据欧盟的“注册，评估，授权和限制化学物质”法规广泛应用于简单混合物暴露。如今，它的使用已作为一种可靠的全污水测试（即复杂混合物暴露测试）在全球范围内推广。但是，实际上没有关于FET在整个废水测试中的效率的同行评审数据。本研究的主要目的是在根据OECD 236进行的FET与世界各地用于全污水测试的其他标准和稍作修改的标准鱼方案之间进行首次比较测试。为此，我们使用了未经处理的医院污水，该污水被认为具有剧毒，但已通过市政污水处理。基本方法是OECD 203（少年），美国环境保护局2000.0（幼虫）和OECD 236（胚胎）。我们还评估了3种几乎无成本的亚致死指标（不动，不孵化和心包水肿），这些指标可以增强OECD 236的敏感性。我们在所有8种测试方法中均观察到了急性毒性，并且敏感性明显提高（幼虫>幼胚）。 。幼虫是整个污水测试中最敏感的生命阶段。经合组织236增加了亚致死指标，将其先前的敏感性提高了30％以上。因此，我们得出的结论是，OECD 236的作用低于其潜能，而胚胎阶段（如FET中所用）可能不是全流出测试最敏感的生命阶段。 Environ Toxicol Chem 2018; 37：2925-2932。 （c）2018年SETAC

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