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首页> 外文期刊>Environmental toxicology and chemistry >FATE OF THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG NAPROXEN IN AGRICULTURAL SOIL RECEIVING LIQUID MUNICIPAL BIOSOLIDS
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FATE OF THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG NAPROXEN IN AGRICULTURAL SOIL RECEIVING LIQUID MUNICIPAL BIOSOLIDS

机译：非甾体抗炎药萘普生在农业土壤中吸收液态城市生物体的命运

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摘要

Naproxen (2-(6-methoxy-2-naphthyl) propionic acid) is widely used for the treatment of pain and swelling associated with arthritis, gout, and other inflammatory conditions. Naproxen has been detected in municipal sewage outflows and in surface waters and could reach agricultural land through the application of municipal biosolids or reclaimed water. The persistence characteristics of naproxen in three agricultural soils were investigated. In laboratory microcosms of moist soil incubated at 30℃, [O-~(14)CH_3]naproxen was rapidly and thoroughly mineralized to ~(14)CO_2 with comparable kinetics in a sandy loam soil, a loam soil, and a silt loam soil. Naproxen mineralization was responsive to soil temperature and soil moisture content, consistent with the primary mechanism of dissipation being biodegradation. Mineralization of naproxen was hastened by the addition of liquid municipal biosolids (LMBs) from a municipal sewage treatment plant that aerated this material. Naproxen was stable in autoclaved soils with or without addition of autoclaved LMBs, whereas naproxen was rapidly mineralized in sterile soil supplemented with nonsterile LMBs. An enrichment culture was obtained from aerobically digested LMBs in a mineral salts medium with naproxen as the sole source of carbon. The culture converted the parent compound to the corresponding naphthol, O-desmethyl naproxen. In summary, naproxen was rapidly removed from soil, with mesophilic aerobic biodegradation being the primary mechanism of dissipation. Microorganisms carried in biosolids enhanced naproxen dissipation in soil, with the initial mechanism of attack likely being O-demethylation. We conclude on this basis that naproxen in soils receiving biosolids would be readily biodegradable and, in the absence of preferential flow or runoff, pose little risk for contamination of adjacent water or crops.
机译：萘普生（2-（6-甲氧基-2-萘基）丙酸）被广泛用于治疗与关节炎，痛风和其他炎症相关的疼痛和肿胀。萘普生已在市政污水流出和地表水中检测到，并可通过应用市政生物固体或再生水到达农用土地。研究了萘普生在三种农业土壤中的持久性特征。在30℃温育的潮湿土壤实验室缩微中，[O-〜（14）CH_3]萘普生在沙壤土，壤土和粉质壤土中被快速，彻底地矿化为〜（14）CO_2。 。萘普生的矿化作用对土壤温度和土壤含水量有响应，这与消散的主要机理是生物降解相一致。萘普生的矿化作用通过添加来自市政污水处理厂的液态市政生物固体（LMB）来加速，该液态市政生物固体对该物质充气。萘普生在添加或不添加高压灭菌的LMB的高压灭菌土壤中稳定，而萘普生在添加了非无菌LMB的无菌土壤中迅速矿化。在萘普生作为唯一碳源的矿物盐培养基中，从需氧消化的LMB中获得富集培养物。培养物将母体化合物转化为相应的萘酚，O-去甲基萘普生。总之，萘普生迅速从土壤中去除，中温需氧生物降解是耗散的主要机理。生物固体中携带的微生物会增强萘普生在土壤中的消散，其最初的攻击机制可能是O-去甲基化。我们在此基础上得出结论，接受生物固体的土壤中的萘普生很容易被生物降解，并且在没有优先流动或径流的情况下，对相邻水或农作物的污染风险很小。

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