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首页> 外文期刊>Environmental toxicology and chemistry >Growth Stimulation Effects of Environmentally Realistic Contaminant Mixtures on a Marine Diatom
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Growth Stimulation Effects of Environmentally Realistic Contaminant Mixtures on a Marine Diatom

机译：环境逼真的污染物混合物对海洋硅藻的生长刺激作用

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摘要

To estimate mixture effects caused by the high number of chemicals simultaneously present in the environment, methods for routine effect assessment of environmentally realistic contaminant mixtures are needed. We repeatedly exposed the marine diatom Phaeodactylum tricornutum to Speedisk(TM) passive sampler extracts and observed statistically significant growth stimulation up to 6 and 7% for samples from inside and outside the harbor of Zeebrugge, respectively. These effects were found at summed contaminant concentrations (159-166 ng L-1) that were within a 1.1- to 2.4-fold range of those observed in grab water samples taken during sampler deployment. These stimulatory effects were confirmed in 2 independent tests with extracts stored for 1 or 8 mo that had undergone limited sample handling, whereas no effects were observed for extracts that had been stored for 16 mo that had undergone repeated handling (notably repeated freezing and thawing) before biotest spiking. Targeted analysis by ultra-high performance liquid chromatography was performed to quantify 88 personal care products (n = 8), pesticides (n = 28), and pharmaceuticals (n = 52). Among these compounds, multivariate statistical analysis put forward the beta-blocker atenolol as explaining most of the observed variation in mixture composition between the growth-stimulating and no effect-causing extracts. However, when tested individually over the entire concentration range present in the extracts, atenolol did not have any effect on P. tricornutum, suggesting that nontargeted substances in the extracts may have contributed to the observed stimulatory effects. Nevertheless, the present study shows that exposure to contaminant mixtures at environmentally realistic concentrations can lead to small but significant growth stimulation effects on the marine diatom P. tricornutum. Environ Toxicol Chem 2019;38:1313-1322. (c) 2019 SETAC
机译：为了估算由环境中同时存在的大量化学物质引起的混合物效应，需要对环境上切实可行的污染物混合物进行常规效应评估的方法。我们反复将海洋硅藻三角藻Phaeodactylum tricornutum暴露于Speedisk（TM）被动采样器提取物中，并观察到Zeebrugge海港内部和外部的样品分别具有高达6％和7％的统计学显着增长。在总污染物浓度（159-166 ng L-1）处发现这些影响，该浓度在采样器部署期间采集的抓水样本中观察到的污染物浓度的1.1至2.4倍之内。这些刺激作用在2次独立测试中得到了证实，对于储存时间小于1或8 mo的提取物，样品进行了有限的处理，而对于经过反复处理（尤其是反复冷冻和解冻）的16 mo的提取物，则未观察到效果。 ），然后再进行生物测试。通过超高效液相色谱进行靶向分析，以定量分析88种个人护理产品（n = 8），农药（n = 28）和药品（n = 52）。在这些化合物中，多变量统计分析提出了β受体阻滞剂阿替洛尔，以解释在刺激生长和无作用的提取物之间的混合物组成中观察到的大多数变化。但是，在提取物中存在的整个浓度范围内进行单独测试时，阿替洛尔对三角果疟原虫没有任何影响，表明提取物中的非靶向物质可能对观察到的刺激作用有所贡献。然而，本研究表明，暴露于环境中实际浓度的污染物混合物中，可能会对海洋硅藻三角锥疟原虫产生小的但显着的生长刺激作用。 Environ Toxicol Chem 2019; 38：1313-1322。 （c）2019年SETAC

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  • 来源
    《Environmental toxicology and chemistry》 |2019年第6期|1313-1322|共10页
  • 作者

    Moeris Samuel; Vanryckeghem Francis; Demeestere Kristof; Huysman Steve; Vanhaecke Lynn; De Schamphelaere Karel A. C.;

  • 作者单位

    Univ Ghent, Fac Biosci Engn, GhEnToxLab, Environm Toxicol Unit,Dept Anim Sci & Aquat Ecol, Ghent, Belgium;

    Univ Ghent, Fac Biosci Engn, Res Grp Environm Organ Chem & Technol EnVOC, Dept Green Chem & Technol, Ghent, Belgium;

    Univ Ghent, Fac Biosci Engn, Res Grp Environm Organ Chem & Technol EnVOC, Dept Green Chem & Technol, Ghent, Belgium;

    Univ Ghent, Fac Vet Med, Lab Chem Anal, Dept Vet Publ Hlth & Food Safety, Merelbeke, Belgium;

    Univ Ghent, Fac Vet Med, Lab Chem Anal, Dept Vet Publ Hlth & Food Safety, Merelbeke, Belgium|Queens Univ, Inst Global Food Secur, Mol Biosci, Sch Biol Sci, Belfast, Antrim, North Ireland;

    Univ Ghent, Fac Biosci Engn, GhEnToxLab, Environm Toxicol Unit,Dept Anim Sci & Aquat Ecol, Ghent, Belgium;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Growth stimulation; Mixture toxicology; Passive sampler; Realistic contaminant mixtures;

    机译：生长刺激;混合物毒理学;被动采样器;真实的污染物混合物;

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