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首页> 外文期刊>Environmental toxicology and chemistry >EFFECTS OF 17α-ETHINYLESTRADIOL AND BISPHENOL A ON VERTEBRAL DEVELOPMENT IN THE FATHEAD MINNOW (PIMEPHALES PROMELAS)
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EFFECTS OF 17α-ETHINYLESTRADIOL AND BISPHENOL A ON VERTEBRAL DEVELOPMENT IN THE FATHEAD MINNOW (PIMEPHALES PROMELAS)

机译：17α-乙撑雌二醇和双酚A对肥头小尾小猪脊柱发育的影响

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Growth, reproductive ability, and metabolic functions may be impaired by disruption of early endocrine patterning. Natural and synthetic estrogens detected in surface waters have been linked to reproductive endocrine signaling disruption in several species. The present study characterizes the nonreproductive morphological endpoint of vertebral anomalies in fish exposed to environmental estrogens. Estrogen is a proliferation-inducing compound in osteoblasts, regulating cartilage and bone deposition during development in vertebrates. The hypothesis for the present work is that xenobiotics with estrogenic activity adversely impact vertebral bone formation. Fathead minnows (Pimephales promelas) were exposed to 0.1 to 100 μg/L 17α-ethinylestradiol (EE2) and 0.1 to 1,000 μg/L bisphenol A (BPA) from egg stage (24 h postfertilization) to 25 to 26 d posthatch. Fish were measured for length and analyzed microscopically to determine degree of skeletal development (developmental score) and the occurrence of spinal abnormalities, including vertebral compression, bone fusion, and spinal curvatures. Fish length and developmental score were inversely related to vertebral malformations in exposed fish. Skeletal developmental was affected significantly in EE2-exposed fish: Vertebral malformations were observed in up to 62% of fish in a nonmonotonic dose-response. However, BPA did not significantly impair skeletal development or induce vertebral malformations. The bioassay results suggest vertebral bone development is a potential endpoint of endocrine disruption from potent estrogenic compounds in surface waters.
机译：早期内分泌模式的破坏可能会损害生长，生殖能力和代谢功能。在地表水中检测到的天然和合成雌激素已与几种物种的生殖内分泌信号转导相关。本研究的特点是暴露于环境雌激素的鱼类中脊椎异常的非生殖形态学终点。雌激素是成骨细胞中的一种诱导增殖的化合物，在脊椎动物发育过程中调节软骨和骨沉积。本研究的假设是具有雌激素活性的异生物素对椎骨的形成有不利影响。从卵期（受精后24 h）到孵化后25 d至26 d，将黑头（Pimephales promelas）暴露于0.1至100μg/ L的17α-乙炔雌二醇（EE2）和0.1至1,000μg/ L的双酚A（BPA）。测量鱼的长度，并进行显微镜分析，以确定骨骼发育的程度（发育评分）和脊柱异常的发生，包括椎骨压缩，骨融合和脊柱弯曲。鱼的长度和发育分数与裸露的鱼的椎骨畸形成反比。暴露于EE2的鱼类的骨骼发育受到显着影响：在非单调剂量反应中，高达62％的鱼类观察到椎骨畸形。但是，BPA并未显着损害骨骼发育或诱发椎骨畸形。生物测定结果表明，椎骨发育是地表水中有效雌激素化合物内分泌破坏的潜在终点。

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