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首页> 外文期刊>Environmental toxicology and chemistry >DOSE VERIFICATION AFTER TOPICAL TREATMENT OF ALLIGATOR (ALLIGATOR MISSISSIPPIENSIS) EGGS
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DOSE VERIFICATION AFTER TOPICAL TREATMENT OF ALLIGATOR (ALLIGATOR MISSISSIPPIENSIS) EGGS

机译：鳄鱼（鳄鱼未成年）进行全面治疗后的剂量验证

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Numerous studies have used temperature-dependent sex determination in reptilian eggs to investigate potential developmental effects of exogenously applied substances. However, few studies have measured the dose carried across the eggshell. We report embryonic mortality and internal egg concentrations determined by gas chromatography-mass spectrometry two weeks after exposure of American alligator (Alligator mississippiensis) eggs to chlorinated organic pesticides via injection or topical application. Puncturing the eggshell for injection produced high mortality compared with unpunctured controls; therefore, further evaluation of this method was abandoned. Although higher than controls, mortality was much lower in eggs treated topically than in those injected. Transfer of chemicals across the eggshell was very low, highly variable, and did not correlate with the applied dose after topical application. These results are consistent with previous reports in the literature, casting doubt on whether a reproducible internal dose can be achieved in reptilian eggs by topical treatment.
机译：大量研究已使用爬虫类卵中温度依赖性性别测定来研究外源施用物质的潜在发育作用。但是，很少有研究测量过蛋壳的剂量。我们通过注射或局部施用将美国短吻鳄（Alligator mississippiensis）卵暴露于氯化有机农药后两周，通过气相色谱-质谱法测定了胚胎死亡率和内部鸡蛋浓度。与未穿刺的对照组相比，穿刺注射用蛋壳的死亡率较高。因此，放弃了对该方法的进一步评估。尽管比对照组要高，但局部处理的卵的死亡率要比注射的卵低得多。跨蛋壳的化学物质转移非常低，变化很大，并且与局部应用后的应用剂量无关。这些结果与以前的文献报道一致，这使人们怀疑通过局部处理能否在爬虫类卵中获得可重复的内部剂量。

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