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首页> 外文期刊>Environmental toxicology and chemistry >KINETIC MODEL OF CADMIUM ACCUMULATION AND ELIMINATION AND METALLOTHIONEIN RESPONSE IN RUDITAPES DECUSSATUS
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KINETIC MODEL OF CADMIUM ACCUMULATION AND ELIMINATION AND METALLOTHIONEIN RESPONSE IN RUDITAPES DECUSSATUS

机译：鱼体内镉累积消除和金属硫蛋白响应的动力学模型。

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摘要

The aim of the present study was to determine the response of metallothionein (MT) during Cd accumulation and elimination in different tissues of the estuarine bivalve Ruditapes decussatus exposed to two nominal Cd concentrations (4 and 40 μg/L) for 40 d, followed by a depuration period of 50 d. Cadmium was accumulated in all tissues of R. decussatus at both exposure concentrations, and the accumulation was tissue dependent. Use of the kinetic model showed that in the gills and remaining tissues, Cd was assimilated faster at the beginning of the exposure and decreased with time, possibly limited by the diffusion rate of this metal within the cell. In the digestive gland, however, the Cd was continuously accumulated. This could reflect that the Cd uptake rate is considerably higher than the loss rate and, therefore, that this tissue has a higher capacity to accumulate Cd compared to the other two tissues. Moreover, the application of this kinetic model in the different subcellular fractions showed that the biocon-centration factor was significantly higher in the low-molecular-weight fraction (where MT is found), suggesting that this fraction binds Cd faster, with a high uptake rate (K_u = 32/d), and eliminates this metal more slowly (K_1 = 0.005/d). During the depuration phase, MT decreased simultaneously with Cd elimination in all tissues, although with a shorter half-life. In conclusion, the MT response prevented Cd in the tissues of R. decussatus from interfering in the normal clam metabolism; therefore, MT acts as a detoxification mechanism of Cd.
机译：本研究的目的是确定在暴露于两种标称Cd浓度（4和40μg/ L）40 d的河口双壳类Ruditapes decussatus不同组织中Cd积累和消除过程中金属硫蛋白（MT）的响应，然后进行40 d净化期为50 d。镉在两种暴露浓度下都在圆角罗汉果的所有组织中积累，并且该积累是组织依赖性的。动力学模型的使用表明，在g和其余组织中，Cd在暴露开始时被更快地吸收，并随时间下降，这可能受该金属在细胞内的扩散速率的限制。然而，在消化腺中，镉不断积累。这可能反映出Cd的吸收率远高于损失率，因此，与其他两个组织相比，该组织具有更高的Cd积累能力。此外，该动力学模型在不同亚细胞级分中的应用表明，低分子量级分（其中存在MT）中的生物浓缩因子明显更高，表明该级分结合Cd的速度更快，吸收率也很高。速率（K_u = 32 / d），并较慢地消除这种金属（K_1 = 0.005 / d）。在净化阶段，尽管半衰期较短，但所有组织中的MT均与Cd消除同时下降。综上所述，MT响应阻止了圆角罗非鱼组织中的Cd干扰正常的蛤代谢。因此，MT可作为Cd的排毒机制。

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