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首页> 外文期刊>Environmental toxicology and chemistry >IMMUNOTOXICITY OF THE COMMERCIAL POLYBROMINATED DIPHENYL ETHER MIXTURE DE-71 IN RANCH MINK (MUSTELA VISON)
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IMMUNOTOXICITY OF THE COMMERCIAL POLYBROMINATED DIPHENYL ETHER MIXTURE DE-71 IN RANCH MINK (MUSTELA VISON)

机译：商业多溴化二苯醚混合物DE-71在水貂皮中的免疫毒性

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Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, organohalogen compounds that are increasing exponentially in the Great Lakes (Canada/USA) biota. The present study was undertaken to examine the immunological effects of a commercial PBDE mixture in ranch mink (Mustela vison). Twenty-week-old mink (n = 10 mink/group) were exposed to 0, 1, 5, or 10 ppm of DE-71 through their diet for eight weeks. The phytohemagglutinin-induced cutaneous reaction, and antibodies specific to keyhole limpet hemocyanin conjugated to dinitrophenol were measured. Liver microsomal ethoxyresorufin-O-deethylase (EROD) activity also was measured. Organs were weighed and spleens were examined histologically. No differences were found in the PHA-induced skin response in exposed mink; mink in the two highest treatments exhibited significant increases in antibody production over control mink. Systemic toxicity was apparent; significant body weight reductions were found in mink exposed to 5 and 10 ppm of DE-71. Exposed mink had significantly larger relative spleen, adrenal, and liver masses than control mink. Spleens of mink exposed to 10 ppm of DE-71 had significantly increased germinal center development and incidence of B-cell hyperplasia. The activity of EROD was induced in all treated mink relative to controls and was positively associated with the liver somatic index. Hematocrit in mink from the two highest exposure groups was significantly lower than control mink. Percentage neutrophils increased and percentage lymphocytes decreased significantly in mink from the higher two dosage groups. Our findings have direct relevance to wild mink in the Great Lakes ecosystem, because mink are top predators of the aquatic food web, providing evidence for the vulnerability of this species to the effects of environmental PBDE mixtures.
机译：多溴二苯醚（PBDEs）是持久的，具有生物蓄积性的有机卤素化合物，在大湖区（加拿大/美国）生物区系中呈指数增长。进行本研究以检查市售多溴二苯醚混合物在牧场水貂（Mustela vison）中的免疫学作用。二十周龄的貂（n = 10只貂/每组）在饮食中暴露于0、1、5或10 ppm的DE-71中八周。测定了植物血凝素引起的皮肤反应，以及对与二硝基苯酚结合的匙孔hole血蓝蛋白特异的抗体。还测量了肝微粒体乙氧基异戊二烯-O-脱乙基酶（EROD）活性。称重器官并进行组织学检查。在暴露的水貂中，PHA诱导的皮肤反应没有发现差异。在两种最高处理方法中，水貂的抗体生成量显着高于对照水貂。全身毒性很明显；暴露于5和10 ppm DE-71的貂皮中发现体重显着降低。暴露的水貂比对照组水貂的脾脏，肾上腺和肝脏肿块明显更大。暴露于10 ppm DE-71的水貂脾脏显着增加了生发中心的发育和B细胞增生的发生率。相对于对照，在所有处理过的水貂中都诱导了EROD的活性，并且与肝脏的体细胞指数呈正相关。来自两个最高暴露水平组的貂的血细胞比容显着低于对照貂。来自两个较高剂量组的貂皮中性粒细胞百分比增加，淋巴细胞百分比明显减少。我们的发现与五大湖生态系统中的野生貂皮直接相关，因为貂皮是水生食物网的主要捕食者，为该物种易受环境多溴二苯醚混合物的影响提供了证据。

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