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首页> 外文期刊>Environmental toxicology and chemistry >Modeling the Effects of Binary Mixtures on Survival in Time
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Modeling the Effects of Binary Mixtures on Survival in Time

机译：模拟二元混合物对存活时间的影响

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摘要

In general, effects of mixtures are difficult to describe, and most of the models in use are descriptive in nature and lack a strong mechanistic basis. The aim of this experiment was to develop a process-based model for the interpretation of mixture toxicity measurements, with effects of binary mixtures on survival as a starting point. The survival of Folsomia Candida was monitored dailg for 21 d during the exposure to six binary mixtures of cadmium, copper, lead, and zinc in a loamy sand soil. The measurement were used to develop a model to describe survival in time. The model consists of two parts: A one-compartment model that describes uptake and elimination of the compounds, and a hazard model describing survival. The model was very successful in describing the data and at finding possible interactions. The mixture of copper and lead showed a slight antagonistic effect, the other mixtures showed no interaction. The model is straightforward in its biological assumptions and does not require a modc-of-action a priori choice of the mixture that might influence the modeled interaction of the components in the mixture. The model requires measurements at intermediate time points, but runs with relatively few parameters and is robust in finding interactions. When mixture effects are considered at only one time point, care should be taken with the assignment of interactions because these may be different for different points during the lime course of the experiments.
机译：通常，混合物的作用很难描述，使用的大多数模型本质上都是描述性的，缺乏强大的机理基础。本实验的目的是建立一个基于过程的模型，用于解释混合物毒性的测量，并以二元混合物对存活率的影响为起点。在壤土质土壤中，镉，铜，铅和锌的六种二元混合物暴露期间，监测了念珠菌的存活21天。该测量用于建立描述生存时间的模型。该模型由两部分组成：描述化合物吸收和消除的单室模型，以及描述生存的危害模型。该模型在描述数据和发现可能的相互作用方面非常成功。铜和铅的混合物显示出轻微的拮抗作用，其他混合物则没有相互作用。该模型在其生物学假设上是简单明了的，不需要先作模型就可以影响混合物中各成分之间相互作用的先验选择。该模型需要在中间时间点进行测量，但是使用相对较少的参数即可运行，并且在发现交互作用方面非常可靠。当仅在一个时间点考虑混合效应时，应注意相互作用的分配，因为在实验的整个过程中，对于不同的点，相互作用可能会有所不同。

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  • 来源
    《Environmental toxicology and chemistry》 |2007年第6期|1320-1331|共12页
  • 作者

    Jan Baas; Bart P.P. van Houte; Cornelis A.M. van Gestel; Sebastiaan A.L.M. Koouman;

  • 作者单位

    Vrije Universiteit Amsterdam, Department of Theoretical Biology, De Boeleiaan 1085, 1081 HV. Amsterdam, The Netherlands;

    Vrije Universiteit Amsterdam, Department of Molecular Cell Physiology, De Boelelaan 1085. 1081 HV, Amsterdam, The Netherlands;

    Vrije Universiteit Amsterdam. Department of Animal Ecology. De Boeleiaan 1085, 1081 HV, Amsterdam, The Netherlands;

    Vrije Universiteit Amsterdam, Department of Theoretical Biology, De Boeleiaan 1085, 1081 HV. Amsterdam, The Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    time modeling; survival; mixtures; interaction;

    机译：时间建模;生存混合物相互作用;

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