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首页> 外文期刊>Environmental toxicology and chemistry >Evaluating Polycyclic Aromatic Hydrocarbons Using a Yeast Bioassay
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Evaluating Polycyclic Aromatic Hydrocarbons Using a Yeast Bioassay

机译：使用酵母生物测定法评估多环芳烃

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摘要

Sixteen polycychc aromatic hydrocarbons (PAHs) were evaluated fur the ability to activate aryl hydrocarbon (Ah) receptor signaling in a yeast-based bioassay. Individual PAHs were classified as inactive or as weakly, moderately, or strongly active based on induction of human Ah receptor signaling. Indeno[1,2,3-cd]pyrene, chrysene, benzo[a]anthracene, benzo[a]pyrene, benzo[j]fluoranthene, and benzo[k]fluoranthene were the most potent activators of human Ah receptor signaling. Various mixtures of PAHs had additive or synergistic effects in the bioassay. Environmental samples from the New Orleans (Louisiana, USA) and Detroit (Michigan, USA) areas that were previously analyzed for PAH composition and quantity were tested in this bioassay. Weak but statistically significant relationships were found when the analytically measured levels of PAHs were correlated with sample dilutions that gave 25% effective concentration signaling levels in the Ah receptor assay. We conclude that this Ah receptor signaling assay may be useful for preliminary biomonitoring of samples for PAHs and other Ah receptor ligands.
机译：在基于酵母的生物测定中，评估了十六种多环芳烃（PAH）活化芳烃（Ah）受体信号传导的能力。基于人Ah受体信号传导的诱导，将各个PAHs分为无活性或弱，中度或强活性。茚并[1,2,3-cd] py 、,、苯并[a]蒽，苯并[a] py，苯并[j]荧蒽和苯并[k]荧蒽是最有效的人类Ah受体信号激活剂。 PAHs的各种混合物在生物测定中具有加和或协同作用。在此生物测定法中测试了先前分析过PAH组成和数量的新奥尔良（美国路易斯安那州）和底特律（美国密歇根州）地区的环境样品。当分析测量的PAHs水平与Ah受体测定中产生25％有效浓度信号水平的样品稀释液相关时，发现微弱但具有统计学意义的关系。我们得出结论，该Ah受体信号传导测定法可能对PAHs和其他Ah受体配体的样品的初步生物监测有用。

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  • 来源
    《Environmental toxicology and chemistry》 |2007年第7期|1333-1339|共7页
  • 作者

    Abeer Alnafisi; Janet Hughes; Guangdi Wang; Charles A. Miller III;

  • 作者单位

    Environmental Health Sciences Department, Center for Bioenvironmental Research and Tulane Cancer Center,New Orleans, Louisiana 70112, USA;

    Biostatistics Department, Tulane University School of Public Health, New Orleans, Louisiana 70112. USA;

    Tropical Medicine and Chemistry Department, Xavier University, New Orleans. Louisiana 70125, USA;

    Environmental Health Sciences Department, Center for Bioenvironmental Research and Tulane Cancer Center,New Orleans, Louisiana 70112, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    dioxin; polycyclic aromatic hydrocarbon; Yeast; bioassay; chemical mixtures;

    机译：二恶英多环芳烃酵母;生物测定化学混合物;

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