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首页> 外文期刊>Environmental toxicology and chemistry >ARE ORGANOHALOGEN CONTAMINANTS A COFACTOR IN THE DEVELOPMENT OF RENAL LESIONS IN EAST GREENLAND POLAR BEARS (URSUS MARITIMUS)?
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ARE ORGANOHALOGEN CONTAMINANTS A COFACTOR IN THE DEVELOPMENT OF RENAL LESIONS IN EAST GREENLAND POLAR BEARS (URSUS MARITIMUS)?

机译：在东部格陵兰北极熊（URSUS MARITIMUS）的视网膜病变发展过程中，有机激素是否是污染物？

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Tissues of polar bears (Ursus maritimus) from East Greenland contain the highest concentrations of organohalogen contaminants (OHCs) among subpopulations of any mammalian species in the Arctic. Negative associations also have been found between OHC concentrations and bone mineral density and liver histology parameters for this subpopulation of polar bears. The present study examined the OHC concentrations and adverse effects on renal tissue for 75 polar bears collected during 1999 to 2002. Specific lesions were diffuse glomerular capillary wall thickening, mesangial glomerular deposits, tubular epithelial cell hyperplasia, hyalinization of the tubular basement membrane, tubular dilatation, atrophy and necrosis, tubular medullary hyalin casts, interstitial fibrosis, and mononuclear cell infiltration. With the exception of mononuclear cell infiltrations, all these parameters were correlated with age, whereas none was associated with the sex of the animals. In an age-controlled statistical analysis of covariance, increases in glomerular mesangial deposits and interstitial fibrosis were significantly (p < 0.05) correlated with po-lybrominated diphenyl ether (ΣPBDE) concentrations in subadults. In adult males, statistically significant (p < 0.05) positive correlations were found for tubular epithelial cell hyperplasia and dieldrin concentration; diffuse glomerular capillary wall thickening and chlordane (ΣCHL) concentrations, and tubular medullary hyalin casts and ΣCHL, ΣPBDE, polychlorinated biphenyl, and hexachlorocyclohexane concentrations. The lesions were consistent with those reported previously in highly OHC-contaminated Baltic seal populations and exposed laboratory animals. The renal lesions were a result of aging. However, based on the above statistical findings as well as the nature of the findings, we suggest that long-term exposure to OHCs may be a cofactor in renal lesion occurrence, although other cofactors, such as exposure to heavy metals and recurrent infections from microorganisms, cannot be ruled out. This is new and important knowledge in the assessment of health status among wildlife populations and humans relying on food resources that are contaminated with OHCs.
机译：东格陵兰岛的北极熊（Ursus maritimus）组织中北极任何哺乳动物物种的亚种群中有机卤素污染物（OHCs）的浓度最高。对于这种北极熊亚群，在OHC浓度与骨矿物质密度和肝脏组织学参数之间也发现了负相关性。本研究检查了1999年至2002年收集的75头北极熊的OHC浓度及其对肾脏组织的不利影响。具体病变包括弥漫性肾小球毛细血管壁增厚，肾小球肾小球沉积物，肾小管上皮细胞增生，肾小管基底膜透明化，肾小管扩张，萎缩和坏死，管状髓质透明质酸管，间质纤维化和单核细胞浸润。除单核细胞浸润外，所有这些参数均与年龄有关，而与动物的性别无关。在年龄相关的协方差统计分析中，亚成人中肾小球系膜沉积和间质纤维化的增加与多溴二苯醚（ΣPBDE）浓度显着相关（p <0.05）。在成年男性中，发现肾小管上皮细胞增生和狄氏剂浓度在统计学上具有显着正相关（p <0.05）。弥漫性肾小球毛细血管壁增厚和氯丹（ΣCHL）浓度，以及管状髓质透明质酸铸模和ΣCHL，ΣPBDE，多氯联苯和六氯环己烷浓度。这些损伤与先前在高度被OHC污染的波罗的海豹种群和暴露的实验动物中报道的一致。肾脏病变是衰老的结果。但是，根据上述统计结果以及研究结果的性质，我们建议长期接触OHC可能是肾脏病变发生的辅助因素，尽管其他辅助因素（例如接触重金属和微生物的反复感染）也是如此。 ，不能排除。这是评估依赖于OHC污染的食物资源的野生动植物种群和人类健康状况的新的重要知识。

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