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首页> 外文期刊>Environmental toxicology and chemistry >Organohalogen contaminants and reproductive hormones in incubating glaucous gulls (Larus hyperboreus) from the Norwegian Arctic.
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Organohalogen contaminants and reproductive hormones in incubating glaucous gulls (Larus hyperboreus) from the Norwegian Arctic.

机译：在孵化挪威北极地区的白垩纪海鸥（Larus hyperboreus）中的有机卤素污染物和生殖激素。

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Organohalogen contaminants detected globally in avian wildlife, including populations from the Arctic, have been related to various reproductive hormone potencies, and altered hormonal balance and functions. Besides legacy organochlorine (OC) substances, that is, polychlorinated biphenyls (PCBs) and OC pesticides and by-products, endocrine-disruptive properties have been defined for chemicals of new and emerging environmental concern, such as polybrominated diphenyl ethers (PBDEs) and metabolically derived products like methylsulfonyl (MeSO2)- and hydroxyl (OH)-PCBs. We investigated the relationships between plasma concentrations of selected legacy OCs, PBDEs, and MeSO2- and OH-PCB metabolites and the circulating reproductive hormones testosterone (T), 17beta-estradiol (E2), and progesterone (P4) in incubating male and female glaucous gulls (Larus hyperboreus) from the Norwegian Arctic. Principal component and regression analyses demonstrated that P4 levels in male glaucous gulls were associated positively with variations of sum (Y) PCB, dichloro-diphenyl-trichloroethane (sigmaDDT), chlordane (sigmaCHL), and sigmaPBDE concentrations, which were the most recalcitrant organohalogens determined in glaucous gulls. No such relationship was found for female glaucous gulls as well as between concentrations of any of the selected organohalogens and levels of T for both sexes. The E2 was not detected in any plasma samples. Present results were highly suggestive that exposure to high organohalogen concentrations in glaucous gulls, particularly the most persistent compound classes, may have the potential to interfere with steroidogenesis and impinge on circulating P4 homeostasis. Because significant effects were found in males exclusively, it cannot be completely ruled out that male glaucous gulls are more sensitive than females to organohalogen-mediated alteration of P4 synthesis and breakdown.
机译：全球范围内在鸟类野生生物（包括北极种群）中检测到的有机卤素污染物与各种生殖激素效力以及荷尔蒙平衡和功能改变有关。除了传统的有机氯（OC）物质（即多氯联苯（PCB）和OC农药和副产品）以外，还为具有新的和新出现的环境问题的化学品（例如多溴联苯醚（PBDEs）和代谢物质）定义了破坏内分泌的特性。衍生产品，例如甲磺酰基（MeSO2）-和羟基（OH）-PCBs。我们研究了在男性和女性白粉病的孵化过程中，选定的传统OC，PBDEs，MeSO2-和OH-PCB代谢物的血浆浓度与循环生殖激素睾丸激素（T），17β-雌二醇（E2）和孕酮（P4）之间的关系。挪威北极的海鸥（Larus hyperboreus）。主成分和回归分析表明，雄性灰质海鸥中的P4水平与总和（Y）PCB，二氯-二苯基-三氯乙烷（sigmaDDT），氯丹（sigmaCHL）和sigmaPBDE浓度的变化呈正相关，这是确定的最难降解的有机卤素在白色的海鸥中。对于雌性白质海鸥，以及任何性别的选定有机卤素的浓度与T水平之间均未发现这种关系。在任何血浆样品中均未检测到E2。目前的结果强烈暗示，暴露于白质海鸥中较高的有机卤素浓度，尤其是最持久的化合物类别，可能会干扰类固醇生成并影响循环中的P4稳态。因为仅在雄性中发现了显着的作用，所以不能完全排除雄性白质鸥比雌性对有机卤素介导的P4合成和分解的改变更敏感。

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