...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental toxicology and chemistry >Photoactivated polycyclic aromatic hydrocarbon toxicity in medaka (Oryzias latipes) embryos: relevance to environmental risk in contaminated sites.
【24h】

Photoactivated polycyclic aromatic hydrocarbon toxicity in medaka (Oryzias latipes) embryos: relevance to environmental risk in contaminated sites.

机译：花（Oryzias latipes）胚胎中的光活化多环芳烃毒性：与受污染地点的环境风险有关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The hazard for photoactivated toxicity of polycyclic aromatic hydrocarbons (PAHs) has been clearly demonstrated; however, to our knowledge, the risk in contaminated systems has not been characterized. To address this question, a median lethal dose (LD50) for fluoranthene photoactivated toxicity in medaka (Orvzias latipes) embryos was determined experimentally and then compared with ultraviolet-A (UV-A; 320-400 nm) radiation exposures in a PAH-contaminated field site. The dose metric, J/cm2/ microg fluoranthene/g egg wet weight, provided the means to estimate risk as the depth where the LD50 level would be exceeded at realistic field PAH concentrations, based on estimates of UV-A exposure. The estimates were made using 30 years of solar radiation data for Duluth (MN, USA) and measurements of water-column UV-A transmittance in a PAH-contaminated field site. Medaka embryo failure was strongly related to tissue PAH concentration and UV-A exposure. The LD50 was estimated to be 12.64 J/cm2/ microg fluoranthene/g egg wet weight; the 95% confidence interval was 8.46 to 19.7 J/cm2/microg fluoranthene/g egg wet weight. Embryo failures were characterized by undifferentiated cell proliferation that occurred very early in development. No partial effects or embryo/larval malformations were observed. Estimates of the depth at which the LD50 would be exceeded in the contaminated field site ranged from 10.7 cm (clear-sky conditions and lowest attenuation) to 0.0 cm (cloudy conditions and highest attenuation). Similar calculations were done using water-column attenuation estimates from 12 sites across the Great Lakes (USA). For these, the depths at which the LD50 would be exceeded ranged from 0.00 to 271.6 cm under the conditions described above. These results suggest that PAH phototoxicity may be a risk factor in specific contaminated sites, and they provide a framework for assessing that risk.
机译：多环芳烃（PAHs）的光活化毒性的危害已得到明确证明；但是，据我们所知，受污染系统的风险尚未得到表征。为了解决这个问题，通过实验确定了aka（Orvzias latipes）胚胎中荧蒽光活化毒性的中值致死剂量（LD50），然后将其与受PAH污染的紫外线-A（UV-A； 320-400 nm）辐射进行比较现场。剂量度量J / cm2 /微克荧蒽/克鸡蛋湿重提供了一种方法，可根据对UV-A暴露的估计，估算在实际田野PAH浓度下超过LD50水平的深度的风险。估算是使用Duluth（美国明尼苏达州）的30年太阳辐射数据以及在受PAH污染的现场中水柱UV-A透射率的测量得出的。 Medaka胚胎衰竭与组织PAH浓度和UV-A暴露密切相关。 LD50估计为12.64 J / cm2 /微克荧蒽/ g鸡蛋湿重。 95％置信区间为8.46至19.7 J / cm2 / microg荧蒽/ g鸡蛋湿重。胚胎衰竭的特征是在发育的早期就发生了未分化的细胞增殖。没有观察到部分影响或胚胎/幼虫畸形。在受污染的野外场所超过LD50的深度估计范围为10.7 cm（晴空条件和最低衰减）至0.0 cm（阴天条件和最高衰减）。使用大湖区（美国）的12个站点的水柱衰减量估算值进行了类似的计算。为此，在上述条件下，超出LD50的深度范围为0.00至271.6 cm。这些结果表明，PAH的光毒性可能是特定污染地点的危险因素，并且它们为评估该危险提供了框架。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号