...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental toxicology and chemistry >Investigating the Impact of Manufacturing Processes on the Ecotoxicity of Carbon Nanofibers: A Multi–Aquatic Species Comparison
【24h】

Investigating the Impact of Manufacturing Processes on the Ecotoxicity of Carbon Nanofibers: A Multi–Aquatic Species Comparison

机译：研究制造工艺对碳纳米纤维的生态毒性的影响：多种水生物种的比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Manufactured nanomaterial production is outpacing the ability to investigate environmental hazard using current regulatory paradigms, causing a backlog of materials requiring testing. To ameliorate this issue, regulatory bodies have proposed integrating safety into the production of novel nanomaterials, allowing for hazards to be identified early in development rather than aftermarket release. In addition, there is a growing interest in short-term ecotoxicity testing to rapidly identify environmental hazards. In this sense, the present study investigated 3 carbon nanofibers (CNFs), created with different production methods, using short-term in vitro and in vivo exposures on fish cell lines, mussel hemocytes, crustacea, and algae. The present study investigated if differences in ecotoxicity hazard between the CNFs could be identified and, if so, which product could be considered less hazardous. A major challenge in assessing the potential hazards posed by manufactured nanomaterials is standardizing the preparation for testing. Standardized operating protocols have been proposed using protein to facilitate the preparation of stable stock suspension, which is not environmentally representative. As such, the study also assessed the potential impacts these standardized protocols (with or without the use of protein) could have on the interpretation of environmental hazard. The results demonstrated that there were clear differences between the 3 CNFs and that the dispersion protocol influenced the interpretation of hazard, demonstrating a need for caution when interpreting ecotoxicity in a regulatory context. Environ Toxicol Chem 2019;38:2314-2325. (c) 2019 SETAC.
机译：纳米材料的人工生产已经超出了使用当前法规范式调查环境危害的能力，从而导致需要测试的材料积压。为了改善这个问题，监管机构建议将安全性纳入新型纳米材料的生产中，以便在开发的早期（而不是在上市后）发现危害。另外，对于短期生态毒性测试以快速识别环境危害的兴趣日益浓厚。从这个意义上讲，本研究调查了3种碳纳米纤维（CNF），这些碳纳米纤维是通过不同的生产方法制成的，使用了鱼类细胞系，贻贝血细胞，甲壳纲动物和藻类的短期体内和体外暴露。本研究调查了CNF之间是否可以识别出生态毒性危害方面的差异，如果可以，则可以认为哪种产品的危害较小。评估人造纳米材料潜在危害的主要挑战是标准化测试准备工作。已经提出使用蛋白质来促进稳定的储备悬浮液的制备的标准化操作方案，这在环境上不具有代表性。因此，该研究还评估了这些标准化方案（使用或不使用蛋白质）对环境危害解释的潜在影响。结果表明，3种CNF之间存在明显差异，并且分散方案影响了危害的解释，表明在监管环境中解释生态毒性时需要谨慎。 Environ Toxicol Chem 2019; 38：2314-2325。 （c）2019年SETAC。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号