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首页> 外文期刊>Environmental toxicology and chemistry >Bioconcentration, Metabolism, and Spatial Distribution of ~(14)C‐Labeled Laurate in the Freshwater Amphipod Hyalella azteca
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Bioconcentration, Metabolism, and Spatial Distribution of ~(14)C‐Labeled Laurate in the Freshwater Amphipod Hyalella azteca

机译：〜（14）C标记的月桂酸盐在淡水两栖类透明质Hyalella azteca中的生物浓度，代谢和空间分布

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摘要

Regulatory assessment of the bioaccumulation from water is commonly based on bioconcentration factors (BCFs) derived from fish flow-through tests. Such experiments require many laboratory animals and are time-consuming and costly. An alternative test setup for organic, neutral compounds using the amphipod Hyalella azteca was recently suggested, resulting in BCF values which show a strong correlation with fish BCF data. In the present study, the bioconcentration potential of the ionic compound laurate was elucidated in H. azteca. The sodium salt of 1-C-14 laurate was applied to H. azteca in a flow-through and a semistatic approach. Because of rapid biodegradation, a semistatic approach with frequent medium replacements was required to ensure a stable medium concentration. Laurate was also rapidly metabolized by H. azteca. A large proportion of the total radioactivity measured in the amphipod tissue was not extractable, suggesting that mineralized laurate was accumulated in the calcified exoskeleton of H. azteca. This was confirmed in a further study using carbonate [C-14]. A lipid-normalized (5.0%) Hyalella BCF of 8.9 was calculated for laurate, measured as free fatty acids. The results of the bioconcentration studies with H. azteca confirm the low bioaccumulation potential of the test item previously observed in fish. However, more organic ionic compounds with various properties need to be tested to assess whether a general correlation between fish and Hyalella BCF data exists. Environ Toxicol Chem 2020;39:310-322. (c) 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.
机译：水中生物富集的法规评估通常基于鱼类流过测试得出的生物富集因子（BCF）。这样的实验需要许多实验动物并且费时且昂贵。最近有人提出了另一种使用两栖类透明质Hyalella azteca对有机中性化合物进行测试的方法，其结果表明BCF值与鱼类BCF数据密切相关。在目前的研究中，阐明了月桂果中离子型化合物月桂酸酯的生物富集潜力。将1-C-14月桂酸酯的钠盐以流水法和半静态法施用于阿兹台克人。由于快速的生物降解，需要使用频繁更换培养基的半静态方法来确保稳定的培养基浓度。月桂酸酯也被阿兹台克人快速代谢。在两栖动物组织中测得的总放射性中有很大一部分是不可提取的，这表明矿化的月桂酸酯积累在阿兹台克人钙化的外骨骼中。使用碳酸盐[C-14]进行的进一步研究证实了这一点。计算出月桂酸酯的脂质归一化（5.0％）Hyalella BCF为8.9，以游离脂肪酸测量。阿兹台克人生物富集研究的结果证实了先前在鱼类中观察到的测试项目的低生物蓄积潜力。但是，需要测试更多具有各种特性的有机离子化合物，以评估鱼类和Hyalella BCF数据之间是否存在一般相关性。 Environ Toxicol Chem 2020； 39：310-322。 （c）2019作者。 Wiley Periodicals，Inc.代表SETAC发布的《环境毒理学和化学》。

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  • 来源
    《Environmental toxicology and chemistry》 |2020年第2期|310-322|共13页
  • 作者

    Raths Johannes; Kuehr Sebastian; Schlechtriem Christian;

  • 作者单位

    Fraunhofer Inst Mol Biol & Appl Ecol Schmallenberg Germany|Rhein Westfal TH Aachen Inst Environm Res Aachen Germany;

    Fraunhofer Inst Mol Biol & Appl Ecol Schmallenberg Germany|Univ Siegen Dept Chem & Biol Ecotoxicol Work Grp Siegen Germany;

    Fraunhofer Inst Mol Biol & Appl Ecol Schmallenberg Germany|Rhein Westfal TH Aachen Inst Environm Res Aachen Germany|Univ Siegen Dept Chem & Biol Ecotoxicol Work Grp Siegen Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Lauric acid; Dodecanoic acid; Bioconcentration of ionic organic compounds; Alternative test systems;

    机译：月桂酸;十二酸;离子有机化合物的生物浓缩;替代测试系统;

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