...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental toxicology and chemistry >Impacts of Sex and Exposure Duration on Gene Expression in Zebrafish Following Perfluorooctane Sulfonate Exposure
【24h】

Impacts of Sex and Exposure Duration on Gene Expression in Zebrafish Following Perfluorooctane Sulfonate Exposure

机译：性别和暴露时间对全氟辛烷磺酸暴露后斑马鱼基因表达的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Perfluorooctane sulfonate (PFOS) is a member of the anthropogenic class of perfluorinated alkyl acids (PFAAs) and one of the most frequently detected PFAAs in water, humans, mammals, and fish around the world. The zebrafish (Danio rerio) is a small freshwater fish considered an appropriate vertebrate model for investigating the toxicity of compounds. Previous investigations showed tissue-specific bioaccumulation and alterations in the expression of fatty acid-binding proteins (fabps) in male and female zebrafish, potentially due to interactions between PFAA and fatty acid transporters. In addition, a number of neurological impacts have been reported as a result of human and animal exposure to PFAAs. Therefore, the present comprehensive study was designed to investigate whether PFOS exposure affects the expression of genes associated with fatty acid metabolism (fabp1a, fabp2, and fabp10a) in zebrafish liver, intestine, heart, and ovary and genes involved in the nervous system (acetylcholinesterase, brain-derived neurotrophic factor, choline acetyltransferase, histone deacetylase 6, and nerve growth factor) in brain and muscle. The results indicate alterations in expression of genes associated with fatty acid metabolism and neural function that vary with both exposure concentration and sex. In addition, our findings highlight that expression of these genes differs according to exposure duration. The present results extend the knowledge base on PFOS effects to other tissues less often studied than the liver. The findings of the present investigation provide a basis for future studies on the potential risks of PFOS as one of the most abundant PFAAs in the environment. Environ Toxicol Chem 2019;00:1-13. (c) 2019 SETAC
机译：全氟辛烷磺酸盐（PFOS）是人为造成的全氟烷基酸（PFAA）类的一员，并且是全世界水，人类，哺乳动物和鱼类中最常检测到的PFAA之一。斑马鱼（Danio rerio）是一种小型淡水鱼，被认为是研究化合物毒性的合适脊椎动物模型。先前的研究表明，雄性和雌性斑马鱼中特定于组织的生物蓄积和脂肪酸结合蛋白（fabps）表达的改变，可能是由于PFAA与脂肪酸转运蛋白之间的相互作用所致。另外，由于人和动物暴露于PFAA，已经报道了许多神经学影响。因此，本综合研究旨在调查全氟辛烷磺酸暴露是否影响斑马鱼肝，肠，心脏和卵巢中与脂肪酸代谢相关的基因（fabp1a，fabp2和fabp10a）的基因表达以及神经系统涉及的基因（乙酰胆碱酯酶） ，脑和肌肉中的脑源性神经营养因子，胆碱乙酰基转移酶，组蛋白脱乙酰基酶6和神经生长因子）。结果表明，与脂肪酸代谢和神经功能相关的基因表达变化随暴露浓度和性别而变化。另外，我们的发现突出表明这些基因的表达根据暴露持续时间而有所不同。目前的研究结果将全氟辛烷磺酸作用的知识扩展到了比肝脏更少研究的其他组织。本次调查的结果为未来研究全氟辛烷磺酸作为环境中最丰富的全氟辛烷磺酸之一的潜在风险提供了基础。 Environ Toxicol Chem 2019; 00：1-13。 （c）2019年SETAC

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号