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首页> 外文期刊>Environmental toxicology and chemistry >RESPONSES OF MOLECULAR INDICATORS OF EXPOSURE IN MESOCOSMS: COMMON CARP (CYPRINUS CARPIO) EXPOSED TO THE HERBICIDES ALACHLOR AND ATRAZINE
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RESPONSES OF MOLECULAR INDICATORS OF EXPOSURE IN MESOCOSMS: COMMON CARP (CYPRINUS CARPIO) EXPOSED TO THE HERBICIDES ALACHLOR AND ATRAZINE

机译：潮气中分子暴露指标的反应：暴露于除草剂和阿曲嗪的鲤鱼（鲤鱼）

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摘要

Common carp (Cyprinus carpio) were treated in aquatic mesocosms with a single pulse of the herbicides atrazine or alachlor to study the bioavailability and biological activity of these herbicides using molecular indicators: Liver vitellogenin gene expression in male fish for estrogenic activity, liver cytochrome P4501A1 gene expression, and DNA damage in blood cells using the single-cell gel electrophoresis method. Both alachlor and atrazine showed dose-related increases in DNA strand breaks at environmentally relevant concentrations (<100 ppb). Gene expression indicators showed that neither herbicide had estrogenic activity in the carp, whereas atrazine at concentrations as low as 7 ppb induced cytochrome P4501A1. These results support the study of molecular indicators for exposure in surrogate ecosystems to gauge relevant environmental changes following herbicide treatments.
机译：对单鲤（Cyprinus carpio）在水生中膜中进行单脉冲除草剂阿特拉津或甲草胺处理，以利用分子指标研究这些除草剂的生物利用度和生物活性：雄性鱼类中卵黄蛋白原基因表达的雌激素活性，肝细胞色素P4501A1基因单细胞凝胶电泳法检测血细胞中的表达和DNA损伤。甲草胺和at去津在环境相关浓度（<100 ppb）下均显示剂量相关的DNA链断裂增加。基因表达指标表明，除草剂均未在鲤鱼中具有雌激素活性，而阿特拉津在低至7 ppb的浓度下可诱导细胞色素P4501A1。这些结果支持研究替代生态系统中暴露的分子指标，以评估除草剂处理后相关的环境变化。

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