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首页> 外文期刊>Environmental toxicology and chemistry >RELATIONSHIPS BETWEEN POLYCHLORINATED BIPHENYLS AND HEALTH STATUS IN HARBOR PORPOISES (PHOCOENA PHOCOENA) STRANDED IN THE UNITED KINGDOM
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RELATIONSHIPS BETWEEN POLYCHLORINATED BIPHENYLS AND HEALTH STATUS IN HARBOR PORPOISES (PHOCOENA PHOCOENA) STRANDED IN THE UNITED KINGDOM

机译：联合王国海螯虾（PHOCOENA PHOCOENA）中多氯联苯与健康状况之间的关系

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摘要

To investigate possible relationships between polychlorinated biphenyl (PCB) exposure and infectious disease mortality in harbor porpoises (Phocoena phocoena) in United Kingdom waters, summed blubber concentrations of 25 chlorobiphenyl congeners (Σ25CB) in healthy harbor porpoises that died of acute physical trauma (mainly by-catch; n = 175) were compared with Σ25CB values in animals that died of infectious disease (n = 82). The infectious disease group had significantly greater Σ25CB values (mean, 27.6mg/kg lipid) than the physical trauma group (mean, 13.6mg/kg lipid; p < 0.001). This association occurred independently of other potentially confounding variables, including age, sex, two indices of nutritional status, season, region, and year found. Total blubber PCB levels (as Aroclor 1254) were also calculated, enabling direct comparison with a proposed threshold for adverse health effects (including immunosuppression) in marine mammals of 17 mg/kg lipid. In porpoises with total PCB levels greater than 17 mg/kg lipid (n = 154), total PCB levels were significantly higher in the infectious disease group compared to the physical trauma group (p < 0.001). This association was no longer significant in porpoises with total PCB levels of less than 17 mg/kg lipid (n = 103; p > 0.55). These findings are consistent with a causal (immunotoxic) relationship between PCB exposure and infectious disease mortality, and they provide a framework for future quantitative risk-assessment analyses of porpoise populations of known size and PCB exposure.
机译：为了调查英国海域海豚（Phocoena phocoena）中多氯联苯（PCB）的暴露与传染病死亡率之间的可能关系，总结了健康海豚中25种氯联苯同类物（Σ25CB）的脂含量，这些海豚因急性身体创伤而死亡（主要是通过-捕获； n = 175）与死于传染病的动物（n = 82）的Σ25CB值进行比较。传染病组的Σ25CB值（均值，27.6mg / kg脂质）显着高于物理创伤组（均值，13.6mg / kg脂质； p <0.001）。这种关联独立于其他可能混淆的变量而发生，包括年龄，性别，营养状况的两个指标，季节，地区和发现的年份。还计算了总的脂类PCB含量（如Aroclor 1254），可以直接与拟议的17 mg / kg脂质海洋哺乳动物的不良健康影响（包括免疫抑制）阈值进行比较。在海豚体内总PCB含量大于17 mg / kg脂质（n = 154）时，与物理创伤组相比，传染病组的总PCB含量显着更高（p <0.001）。在总PCB含量低于17 mg / kg脂质的海豚中，这种关联不再显着（n = 103； p> 0.55）。这些发现与多氯联苯暴露与传染病死亡率之间的因果关系（免疫毒性）一致，并且它们为已知规模和多氯联苯暴露的海豚种群的未来定量风险评估分析提供了框架。

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