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首页> 外文期刊>Environmental toxicology and chemistry >AROCLOR 1254 EXPOSURE REDUCES DISEASE RESISTANCE AND INNATE IMMUNE RESPONSES IN FASTED ARCTIC CHARR
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AROCLOR 1254 EXPOSURE REDUCES DISEASE RESISTANCE AND INNATE IMMUNE RESPONSES IN FASTED ARCTIC CHARR

机译：AROCLOR 1254暴露可减轻北极冰沙中的疾病抵抗力和固有的免疫反应

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摘要

To examine the immunological impacts of polychlorinated biphenyls (PCBs) in an environmentally relevant way, we orally contaminated Arctic charr (Salvelinus alpinus) with Aroclor 1254. After contamination, fish were either fed (0 and 100 mg Aroclor 1254 kg~(-1) fish wt) or fasted (0, 1, 10, and 100 mg kg~(-1)) to mimic cycles of feeding-fasting experienced by Arctic animals. After four months, PCB concentrations in muscle were the same in fasted and fed fish; however, PCBs in kidneys of fed fish were 33 to 50% of those in fasted fish. Arctic charr were exposed to Aeromonas salmonicida, the bacteria responsible for furunculosis, by cohabitation with infected conspecifics. Fasted fish had a significant trend toward lower survival with higher dose of PCBs— from 68% in controls to 48% in treatment involving 100 mg kg~(-1). Independent of PCB contamination, fed fish had the lowest survival; we attribute this to stress associated with establishing and maintaining feeding hierarchies. A significant decrease in the activity of lysozyme was observed in skin mucus, as was hemagglutination ability of a putative rhamnose lectin in fasted, but not in fed, PCB-treated fish. These results demonstrate the immunosuppressive effects of PCBs on Arctic charr, and they illustrate the importance of considering environmentally relevant nutritional status in ecotoxicological studies.
机译：为了以环境相关的方式检查多氯联苯（PCB）的免疫学影响，我们用Aroclor 1254口服污染了北极鲑（Salvelinus alpinus）。污染后，喂鱼（0和100 mg Aroclor 1254 kg〜（-1））鱼体重）或禁食（0、1、10和100 mg kg〜（-1））以模仿北极动物经历的禁食周期。四个月后，禁食和喂食鱼的肌肉中PCB含量相同；然而，饲喂鱼肾脏中的多氯联苯占禁食鱼肾脏中多氯联苯的33％至50％。通过与受感染的同种同居，北极鲑鱼暴露于引起沙门氏菌的细菌沙门气单胞菌。禁食鱼具有较高的多氯联苯剂量，导致其存活率降低的显着趋势-从对照的68％到涉及100 mg kg〜（-1）的治疗的48％。不受多氯联苯污染的影响，喂鱼的存活率最低。我们将此归因于与建立和维护饲养层级结构相关的压力。观察到在皮肤粘液中溶菌酶的活性显着降低，在空腹但未经PCB处理的鱼中，假定的鼠李糖凝集素的血凝能力也是如此。这些结果证明了多氯联苯对北极鲑鱼的免疫抑制作用，并且它们说明了在生态毒理学研究中考虑与环境有关的营养状况的重要性。

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