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首页> 外文期刊>Environmental toxicology and chemistry >Relationship between ethinylestradiol-mediated changes in endocrine function and reproductive impairment in Japanese medaka (Oryzias latipes).
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Relationship between ethinylestradiol-mediated changes in endocrine function and reproductive impairment in Japanese medaka (Oryzias latipes).

机译：乙炔雌二醇介导的内分泌功能变化与日本（Oryzias latipes）的生殖功能障碍之间的关系。

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摘要

Many biochemical endpoints currently are used to describe endocrine function in fish; however, the sensitivity of these parameters as biomarkers of impaired reproduction or sexual development is not well understood. In the present study, adult Japanese medaka (Oryzias latipes) were assessed for reproductive output and endocrine function, including circulating steroid concentrations, ex vivo steroidogenesis from the gonads, aromatase activity, hepatic estrogen receptor (ER), and plasma vitellogenin (VTG) after exposure to 0, 0.2, 5, 500, and 2,000 ng/L of 17alpha-ethinylestradiol (EE) for 14 d. The EE altered these biochemical responses at various sites along the hypothalamus-pituitary-gonadal axis at concentrations as low as 0.2 ng/L, but it only depressed reproductive function at concentrations of 500 ng/L or greater. Offspring also had reduced ability to hatch at 500 ng/L of EE, but this concentration did not produce any other observed changes in development or sexual phenotype. The reproductive parameters correlated well with VTG, ER, and gonadosomatic index (GSI) in both sexes of adult medaka, which could be indicative of the ER-mediated mode of action for EE. Vitellogenin and ER were elevated at higher concentrations of EE in both sexes, whereas GSI was decreased. Overall, most biochemical endpoints were more sensitive than reproduction or development to exposure, indicating that reproductive function may be relatively protected.
机译：当前，许多生化终点被用来描述鱼类的内分泌功能。然而，这些参数作为生殖或性发育受损的生物标志物的敏感性尚不十分清楚。在本研究中，对成年日本（Oryzias latipes）的生殖输出和内分泌功能进行了评估，包括循环类固醇浓度，性腺的离体类固醇生成，芳香化酶活性，肝雌激素受体（ER）和血浆卵黄蛋白原（VTG）。暴露于0、0.2、5、500和2,000 ng / L的17α-炔雌醇（EE）中14天。 EE在低至0.2 ng / L的浓度下沿下丘脑-垂体-性腺轴的各个部位改变了这些生化反应，但在500 ng / L或更高的浓度下仅降低了生殖功能。后代在EE为500 ng / L时孵化的能力也有所降低，但这种浓度并未在发育或性表型上产生任何其他观察到的变化。在青成年男女中，生殖参数与VTG，ER和性腺机能指数（GSI）密切相关，这可能表明ER介导的EE作用方式。卵黄蛋白原和雌激素在较高的EE浓度下均升高，而GSI降低。总体而言，大多数生化终点指标比生殖或发育对接触更为敏感，表明生殖功能可能受到相对保护。

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