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The use of terrestrial and aquatic microcosms and mesocosms for the ecological risk assessment of veterinary medicinal products.

机译:陆生和水生微观世界和中观世界在兽药产品生态风险评估中的应用。

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In this paper, we investigate the applicability of experimental model ecosystems (microcosms and mesocosms) for the ecological risk assessment of veterinary medicinal products (VMPs). VMPs are used in large quantities, but the assessment of associated risks to the environment is limited, although they are continually infused into the environment via a number of routes. It is argued that the experience obtained by pesticide research largely can be used when evaluating VMPs, although there are several major differences between pesticides and pharmaceuticals (e.g., knowledge of their mechanisms of action on nontarget organisms). Also, because microorganisms are often the target organisms of VMPs, risk assessment should focus more on endpoints describing functional processes. This paper provides a review of the current risk assessment schemes of Europe and North America along with examples of experiments already performed with veterinary medicinal products in aquatic and terrestrial ecosystem models. We suggest that some of the approaches developed for pesticide risk assessment can be used for VMPs and offer suggestions for the development of a framework for ecological risk assessment of VMPs.
机译:在本文中,我们调查了实验模型生态系统(微观和中观)在兽药产品(VMPs)生态风险评估中的适用性。 VMP被大量使用,但是对环境的相关风险的评估是有限的,尽管它们通过多种途径不断注入环境中。有人认为,尽管农药和药物之间存在若干主要差异(例如,了解其对非目标生物的作用机理的知识),但农药研究中获得的经验在很大程度上可用于评估VMP。此外,由于微生物通常是VMP的目标生物,因此风险评估应更多地关注于描述功能过程的终点。本文概述了欧洲和北美目前的风险评估方案,以及已经在水生和陆地生态系统模型中使用兽药进行实验的实例。我们建议开发用于农药风险评估的某些方法可用于VMP,并为建立VMP生态风险评估框架提供建议。

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