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首页> 外文期刊>Environmental toxicology and chemistry >DERMAL BIOAVAILABILITY OF BENZO[a]PYRENE ON LAMPBLACK: IMPLICATIONS FOR RISK ASSESSMENT
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DERMAL BIOAVAILABILITY OF BENZO[a]PYRENE ON LAMPBLACK: IMPLICATIONS FOR RISK ASSESSMENT

机译：苯并[a] Y在蓝黑上的皮肤生物利用度：对风险评估的影响

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摘要

Lampblack is the principal source of contamination in soils at manufactured gas plant (MGP) sites where oil was used as the feedstock. Risks and cleanup criteria at these sites are determined primarily by the total carcinogenic polynuclear aromatic hydrocarbon (PAH) content, particularly the concentration of benzo[a]pyrene (BaP). Dermal contact with .soils at oil-gas MGP sites is a significant component of the overall risks. Seven samples were collected from oil—gas MGP sites and the steady-state dermal fluxes were measured over 96 h in vitro. The standard dermal bioassay technique (in which ~3H-BaP is added to the soil matrix) was modified to allow direct measurement of the dermal absorption of the native BaP in the samples. The experimentally derived dermal absorption factors for BaP were 14 to 107 times lower than the default assumption of 15% over 24 h (55-fold lower on average). The dermal fluxes were correlated positively to the total BaP and total carbon concentrations. The measured dermal absorption factors were compared to the default risk-assessment calculations for all seven samples. The calculated excess cancer risk was reduced as a result of using the measured absorption factors by 97% on average (with reductions ranging from 93 to 99%). This work indicates the risks at oil-gas MGP sites currently are overestimated by one to two orders of magnitude, and provides a protocol for the testing and data analysis needed to generate site-specific cleanup levels.
机译：油烟粉是人造油厂（MGP）场地土壤的主要污染源，这些地方以石油为原料。这些地点的风险和清除标准主要由致癌多核芳烃（PAH）的总量，特别是苯并[a] re（BaP）的浓度决定。在油气MGP现场与土壤的皮肤接触是整体风险的重要组成部分。从油气MGP站点收集了七个样本，并在体外96小时内测量了稳态皮肤通量。修改了标准的皮肤生物测定技术（将〜3H-BaP添加到土壤基质中），以直接测量样品中天然BaP的皮肤吸收。通过实验得出的BaP的皮肤吸收因子比默认假设低24％（15％在24小时内）低14至107倍（平均低55倍）。皮肤通量与总BaP和总碳浓度呈正相关。将测得的皮肤吸收因子与所有七个样品的默认风险评估计算结果进行比较。通过使用测量的吸收系数，平均计算出的癌症风险降低了97％（降低的范围是93％至99％）。这项工作表明，目前油气MGP站点的风险被高估了一到两个数量级，并为生成特定于站点的清理级别提供了用于测试和数据分析的协议。

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