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首页> 外文期刊>Environmental toxicology and chemistry >DEGRADATION OF CITALOPRAM BY SIMULATED SUNLIGHT
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DEGRADATION OF CITALOPRAM BY SIMULATED SUNLIGHT

机译：模拟阳光下柠檬醛的降解

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Citalopram (CIT), 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-5-phthalancarbonitrile, a selective serotonin reuptake inhibitor, is one of the most widely used antidepressants for the treatment of anxiety, obsessional, and control disorders. The degradation of the pharmaceutical CIT hydrogen bromide in water was investigated in the dark and in a growth chamber outfitted with fluorescent lamps simulating the ultraviolet output of sunlight at 25℃. No significant degradation could be detected in dark controls in any aqueous solution investigated over a period of 30 d. Citalopram degraded less than 0.5% at pH 5 and pH 7 during the 30-d exposure period under simulated sunlight. However, at pH 9, CIT moderately degraded, with a half-life of 65 d via a pseudo-first order kinetic model. Degradation was faster in synthetic humic water (half-life, 24 d) and in natural waters (half-lives, 14 and 43 d) than in pH 9 buffer, indicating photosensitization by humic acid or other materials in water. Two photoproducts were detected over the irradiation period, and their structures were identified as N-desmethylcitalopram (DCIT) produced by N-demeth-ylation as a major product and CIT N-oxide by N-oxygenation as a minor product by liquid chromatography-electrospray ionization-mass spectrometry. The DCIT appeared to be hydrolytically and photolytically stable in aqueous environments. In conclusion, CIT and DCIT were relatively stable in various solutions including natural waters. However, they may dissipate from the aqueous phase to some extent, possibly because of adsorption in real environments where soils and sediments exist.
机译：西酞普兰（CIT）1-（3-二甲基氨基丙基）-1-（4-氟苯基）-5-邻苯二甲腈是一种选择性的5-羟色胺再摄取抑制剂，是最广泛使用的抗抑郁药，用于治疗焦虑症，强迫症和控制性疾病。在黑暗中和装有荧光灯的生长室中研究了药用CIT溴化氢在水中的降解情况，该室装有荧光灯，可模拟25℃下太阳光的紫外线输出。在30天内研究的任何水溶液中，深色对照中均未检测到明显的降解。在模拟阳光下30 d暴露期间，西酞普兰在pH 5和pH 7下降解不到0.5％。然而，在pH 9时，CIT通过拟一级动力学模型适度降解，半衰期为65 d。与pH 9缓冲液相比，合成腐殖质水（半衰期24 d）和天然水（半衰期14和43 d）的降解速度更快，表明腐殖酸或其他物质在水中的光敏性。在照射期间检测到两种光产物，其结构被鉴定为通过N-去甲基化产生的N-去甲基西酞普兰（DCIT）为主产物，通过液相色谱-电喷雾通过N-氧化产生的CIT N-氧化物为次要产物。电离质谱。 DCIT在水性环境中似乎具有水解和光解稳定性。总之，CIT和DCIT在包括天然水在内的各种解决方案中相对稳定。但是，它们可能在一定程度上从水相中消散，可能是由于在存在土壤和沉积物的真实环境中的吸附。

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