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首页> 外文期刊>Environmental toxicology and chemistry >ACCUMULATION OF HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE IN CHANNEL CATFISH (ICTALURUS PUNCTATUS) AND AQUATIC OLIGOCHAETES (LUMBRICULUS VARIEGATUS)
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ACCUMULATION OF HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE IN CHANNEL CATFISH (ICTALURUS PUNCTATUS) AND AQUATIC OLIGOCHAETES (LUMBRICULUS VARIEGATUS)

机译：通道养鱼（水V属）和水生低聚螯虾（LUMBRICULUS VARIEGATUS）中六水合-1,3,5-三丁-1,3,5-三嗪的积累

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The extensively used military explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) has been widely released to the environment during production, usage, and disposal operations. Toxic effects of RDX have been reported in terrestrial and aquatic receptors, but investigations regarding the bioaccumulation potential of RDX in aquatic systems are scarce. The objective of the present study was to describe the toxicokinetics of RDX during aqueous exposure for the channel catfish (Ictalurus punctatus) and aquatic oligochaetes (Lumbriculus variegatus) and to compare the amount of RDX accumulation in juvenile catfish following aqueous exposure only, dietary exposure only, and a combination of dietary and aqueous exposure. The toxicokinetics measurements included bioconcentration factors (BCFs), uptake rates, elimination rates, and biological half-lives. First-order, single-compartment models described the toxicokinetics for both species. Uptake of RDX into oligochaetes was relatively rapid (uptake clearance constant [k_u] of 5.17 ml/g/h) compared to that in catfish (k_u= 1.28 ml/g/h). However, elimination also was more rapid in oligochaetes, with biological half-lives of 0.28 and 1.09 h for oligochaetes and catfish, respectively. Thus, both species had very similar estimated BCFs of 2.1 ml/g for oligochaetes and 2.0 ml/g for catfish. Accumulation of RDX in fish that were fed oligochaetes exposed to an exceedingly high water concentration of RDX was minimal. The present investigation indicates that RDX uptake via the aqueous route is the expected dominant uptake pathway, with dietary uptake contributing minimally to the overall body burden in fish inhabiting RDX-contaminated sites. Because of the exceedingly low bioaccumulative potential and low reported toxicity of RDX, the presence of this explosive in aquatic systems is unlikely to pose unacceptable risks to invertebrates and fish.
机译：广泛使用的军用炸药六氢-1,3,5-三硝基-1,3,5-三嗪（RDX）在生产，使用和处置过程中已广泛释放到环境中。已经报道了RDX在陆生和水生受体中的毒性作用，但是关于RDX在水生系统中的生物蓄积潜力的研究很少。本研究的目的是描述RDX在河cat鱼（Ictalurus punctatus）和水生寡壳动物（Lumbriculus variegatus）的水暴露过程中的毒代动力学，并比较仅在水暴露，仅饮食暴露下的幼cat鱼RDX的积累量。 ，以及饮食和水暴露的结合。毒物代谢动力学测量包括生物浓缩因子（BCF），吸收率，消除率和生物半衰期。一阶单室模型描述了这两种物种的毒代动力学。与cat鱼（k_u ＝ 1.28ml / g / h）相比，RDX向寡毛虫的吸收相对较快（吸收清除常数[k_u]为5.17ml / g / h）。但是，消除寡头类动物的速度也更快，寡头类和cat鱼的生物半衰期分别为0.28和1.09 h。因此，这两种物种的估计BCF值非常相似，寡壳类动物为2.1 ml / g，cat鱼为2.0 ml / g。饲喂暴露于RDX水中浓度极高的寡鱼的鱼类中RDX的积累极少。本研究表明，通过水途径的RDX摄取是预期的主要摄取途径，饮食摄取对居住在受RDX污染的鱼类的总体负担影响最小。由于RDX具有极低的生物累积潜力和较低的毒性，因此这种爆炸物在水生系统中的存在不太可能对无脊椎动物和鱼类构成不可接受的风险。

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