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首页> 外文期刊>Environmental toxicology and chemistry >Utility of morphological abnormalities during early-life development of the estuarine mummichog, Fundulus heteroclitus, as an indicator of estrogenic and antiestrogenic endocrine disruption.
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Utility of morphological abnormalities during early-life development of the estuarine mummichog, Fundulus heteroclitus, as an indicator of estrogenic and antiestrogenic endocrine disruption.

机译：在河口mummichog的早期发育中形态异常的实用性，作为雌激素和抗雌激素内分泌破坏的指标。

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To evaluate the use of morphological abnormalities for standard testing of endocrine-disrupting substances (EDS), we tested the hypothesis that developmental abnormalities are a sensitive indicator of exposure to waterborne estrogenic and antiestrogenic EDS during embryonic, larval, and juvenile stages in the common estuarine killifish, the mummichog (Pisces: Cyprinodontidae). Static exposures with daily renewal were carried out with 10 to 10,000 ng/L of the estrogen agonist 17alpha-ethynylestradiol (EE2) or antagonist ZM189,154 (ZM) for the first 25 or 60 d of life. Incidence of skeletal abnormalities (scoliosis, lordosis, head, craniofacial, jaw, fin) and soft tissue abnormality (anal swelling) were significantly increased by EE2 but only at high concentrations (1,000 or 10,000 ng/L). Sixty-day exposure produced more severe abnormalities than 25-d exposure and in a higher proportion of fish. Within the longer exposure, 10,000 ng/L EE2 produced more abnormal fish than 1,000 ng/L (100% vs 51.6%) and more abnormalities per abnormal fish (5.73 vs 1.47). Fish reared to 12 months in clean water after exposure for 60 d to 10,000 ng/L EE2 survived at a lower rate than controls, retained abnormalities with the exception of anal swelling and, like fish exposed to other concentrations of EE2 and ZM, showed increased weight at length at 6 and 12 months. Sixty-day exposure to ZM increased the incidence of scoliosis (1,000 ng/L) but decreased the overall incidences of abnormal fish and lordosis (10 and 10,000 ng/L). No impacts of EE2 or ZM were observed before hatch, and clearing and staining of larvae demonstrated that expression of vertebral abnormalities coincided temporally with ossification. We conclude that morphological abnormalities in mummichogs are not a sensitive indicator of exposure to estrogenic or antiestrogenic waterborne EDSs at environmentally relevant concentrations.
机译：为了评估形态异常用于内分泌干扰物（EDS）的标准测试中，我们测试了以下假设：发育异常是在普通河口胚胎，幼虫和幼年期暴露于水性雌激素和抗雌激素EDS的敏感指标目鱼，木乃伊（双鱼座：Cyprinodontidae）。在生命的前25或60天，每天用10至10,000 ng / L的雌激素激动剂17α-乙炔基雌二醇（EE2）或拮抗剂ZM189,154（ZM）进行每日更新的静态暴露。 EE2可显着增加骨骼异常（脊柱侧弯，脊柱前凸，头，颅面，颌，鳍）和软组织异常（肛门肿胀）的发生率，但仅在高浓度（1,000或10,000 ng / L）下才发生。 60天的暴露比25天的暴露产生更严重的异常，鱼的比例更高。在更长的暴露时间内，10,000 ng / L EE2产生的异常鱼多于1,000 ng / L（100％比51.6％），每条异常鱼的异常也更多（5.73比1.47）。暴露60 d至10,000 ng / L EE2后，在清水中养育12个月的鱼存活率低于对照组，除肛门肿胀外保留异常，就像暴露于其他浓度EE2和ZM的鱼一样在6和12个月时的体重。 ZM暴露60天增加了脊柱侧弯的发生率（1,000 ng / L），但降低了鱼类和弧菌病异常的总体发生率（10和10,000 ng / L）。孵化前未观察到EE2或ZM的影响，幼虫的清除和染色表明椎骨异常的表达在时间上与骨化相吻合。我们得出结论，木乃伊的形态异常不是环境相关浓度下暴露于雌激素或抗雌激素的水性EDS的敏感指标。

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