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首页> 外文期刊>Environmental toxicology and chemistry >Effects of data manipulation and statistical methods on species sensitivity distributions.
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Effects of data manipulation and statistical methods on species sensitivity distributions.

机译：数据处理和统计方法对物种敏感性分布的影响。

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摘要

Species sensitivity distribution (SSD) methodology currently is used in environmental risk assessment to determine the predicted no-effect concentration (PNEC) of a substance in cases where a sufficient number of chronic ecotoxicological tests have been carried out on the substance, covering, for the aquatic environment with which we are concerned, three taxonomic groups: algae, invertebrates, and vertebrates. In particular, SSD methodology enables calculation of a hazardous concentration that is assumed to protect 95% of species (HC5). This approach is based on the hypothesis that the species for which results of ecotoxicological tests are known are representative, in terms of sensitivity, of the totality of the species in the environment, which raises a number of questions, both theoretical and practical. In this study, we compared various methods of constructing a species sensitivity-weighted distribution (SSWD). Each method is characterized by a different way of taking into account intraspecies variation and proportions of taxonomic groups (vertebrates, invertebrates, and algae), as well as by the statistical method of calculation of the HC5 and its confidence interval. Those methods are tested on 15 substances by using chronic no-observed-effect concentration data available in the literature. The choice of data (intraspecies variation and proportions between taxonomic groups) was found to have more effect on the value of the HC5 than the statistical method used to construct the distribution. The weight of each taxonomic group is the most important parameter for the result of the SSWD and letting literature references decide which proportions of data are used to construct it is not satisfactory.
机译：在已经对该物质进行了足够数量的长期生态毒理学测试的情况下，目前在环境风险评估中使用物种敏感度分布（SSD）方法来确定该物质的预计无效应浓度（PNEC）。我们关注的水生环境分为三个生物分类群：藻类，无脊椎动物和脊椎动物。特别是，SSD方法论能够计算被认为可以保护95％的物种（HC5）的危险浓度。这种方法基于以下假设：就敏感性而言，已知生态毒理学测试结果的物种代表环境中物种的总数，这提出了许多理论和实践问题。在这项研究中，我们比较了构建物种敏感度加权分布（SSWD）的各种方法。每种方法的特点是采用不同的方式来考虑物种内变异和生物分类群（脊椎动物，无脊椎动物和藻类）的比例，以及通过计算HC5及其置信区间的统计方法。通过使用文献中提供的长期无观测效应浓度数据，对15种物质进行了测试。发现数据的选择（物种内差异和分类组之间的比例）比用于构建分布的统计方法对HC5值的影响更大。每个分类组的权重是SSWD结果的最重要参数，让文献参考来决定使用哪个比例的数据来构造它是不令人满意的。

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