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首页> 外文期刊>Environmental toxicology and chemistry >REPRODUCTIVE EFFECTS OF ESTROGENIC AND ANTIESTROGENIC CHEMICALS ON SHEEPSHEAD MINNOWS (CYPRINODON VARIEGATUS)
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REPRODUCTIVE EFFECTS OF ESTROGENIC AND ANTIESTROGENIC CHEMICALS ON SHEEPSHEAD MINNOWS (CYPRINODON VARIEGATUS)

机译：雌激素和抗雌激素药物对蛇头的繁殖作用

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Environmental estrogens can activate genes of the reproductive system, such as vitellogenin (VTG), a precursor to egg yolk protein, by activating the estrogen receptor (ER), whereas antiestrogens can inhibit ER activation. Adult lab-reared male sheepshead minnows (Cyprinodon variegatus) were exposed to estrogenic 4-tert-octylphenol (OP) and females to antiestrogenic cadmium (Cd), and the effects on four potential indicators of impaired reproductive function were examined: VTG in F_0 male blood as sign of feminization, F_0 generation fecundity/fertility, embryonic development/egg hatching/survival rate of F_1 generation fry, and F_0 gonadal histology. Mean VTG in the control, 11.5, 33.6, and 61.1 μg/L OP male fish were 0, 10.7, 38.7, and 65.6 mg/ml postexposure and 0, 2.5, 19.4, and 30.0 mg/ml postreproduction. A significant inverse relationship between increasing VTG in male blood and reproductive success of mating groups involving these males was shown, with higher OP decreasing percent viable eggs (fertility) by approximately 60%. Histology showed increased testis anomalies and decreased spermatozoa with increasing OP exposure. No effects on F_1 embryonic development, egg hatching, or fry survival rate were observed. A significant decline in percent viable egg production involving Cd-exposed females occurred only when mated with OP-exposed males, with no eggs produced by fish exposed to the highest OP and Cd concentration. A three-week field exposure near a wastewater treatment plant outfall showed no elevated VTG in male plasma, but significantly higher total egg production per female per collection day (～45%) was observed at the site furthest from the outfall.
机译：环境雌激素可以通过激活雌激素受体（ER）来激活生殖系统的基因，例如卵黄蛋白原（VTG）（蛋黄蛋白的前体），而抗雌激素可以抑制ER激活。成年实验室饲养的雄性羊头min鱼（Cyprinodon variegatus）暴露于雌激素的4-叔辛基苯酚（OP），雌性暴露于抗雌激素的镉（Cd），并研究了其对生殖功能受损的四个潜在指标的影响：F_0雄性中的VTG血液作为女性化的标志，F_0代的繁殖力/受精能力，F_1代鱼苗的胚胎发育/卵孵化率/存活率以及F_0的性腺组织学。对照，11.5、33.6和61.1μg/ L OP雄鱼的平均VTG分别为暴露后0、10.7、38.7和65.6 mg / ml，以及繁殖后0、2.5、19.4和30.0 mg / ml。结果表明，雄性血液中的VTG增加与这些雄性交配组的繁殖成功之间存在显着的负相关关系，较高的OP降低了活卵百分比（育性）约60％。组织学显示，随着OP暴露的增加，睾丸异常增加，精子减少。没有观察到对F_1胚胎发育，卵孵化或鱼苗成活率的影响。仅当与暴露于OP的雄性交配时，涉及Cd的雌性的活卵生产百分比才会显着下降，而暴露于最高OP和Cd浓度的鱼不会产卵。在废水处理厂排污口附近进行的为期三周的野外暴露表明，雄性血浆中的VTG并未升高，但在距排污口最远的位置，每个雌性每收集日的总产卵量明显更高（〜45％）。

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