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首页> 外文期刊>Environmental toxicology and chemistry >1-HYDROXYPYRENE GLUCURONIDE AS THE MAJOR AQUEOUS PYRENE METABOLITE IN TISSUE AND GUT FLUID FROM THE MARINE DEPOSIT-FEEDING POLYCHAETE NEREIS DIVERSICOLOR
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1-HYDROXYPYRENE GLUCURONIDE AS THE MAJOR AQUEOUS PYRENE METABOLITE IN TISSUE AND GUT FLUID FROM THE MARINE DEPOSIT-FEEDING POLYCHAETE NEREIS DIVERSICOLOR

机译：1-羟基Y葡糖苷作为来自海洋沉积物的多酚类NEREIS DIVERSICOLOR的组织和肠液中主要的P代谢物

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摘要

Both 1-hydroxypyrene and 1-hydroxypyrene glucuronide are identified as the primary phase Ⅰ and phase Ⅱ metabolites of the four-ringed polyeyclic aromatic hydrocarbon (PAH) pyrene in the marine deposit-feeding polychacte Nereis diversicolor. Identification of pyrene and primary metabolites was performed using high-pressure liquid chromatography (HPLC) with diode-array detection and fluorescence detection (HPLC/DAD/F) and an ion-trap mass spectrometer for positive identification of 1-hydroxypyrene glucuronide. Besides 1-hydroxypyrene and 1-hydroxypyrene glucuronide, the HPLC/F trace of tissue samples from pyrene-exposed worms showed three additional low-intensity peaks that may be related to pyrene metabolism based on similar excitation/emission wavelengths. The peaks were all too low in intensity to be positively identified. Of the total PAH in tissue, 1-hydroxypyrene glucuronide, 1-hydroxypyrene, and pyrene constituted 73%, 2%, and 25% respectively. Gut elimination of metabolic products is supported by the identification of 1 -hydroxypyrene and 1 -hydroxypyrene glucuronide in both gut fluid and defecation water. Being the only phase Ⅰ metabolite of pyrene, 1-hydroxypyrene becomes a useful marker for PAH exposure, and it may serve as a valuable model compound for assessing species-specific PAH metabolic capabilities.
机译：1-羟基py和1-羟基py葡糖苷酸都被认为是海洋沉积物饲养多异性奈里氏菌四环多环芳烃hydrocarbon的主要Ⅰ相和Ⅱ相代谢产物。 using和一级代谢物的鉴定使用带有二极管阵列检测和荧光检测（HPLC / DAD / F）的高压液相色谱（HPLC）以及用于正向鉴定1-羟基py葡糖醛酸的离子阱质谱仪进行。除1-羟基py和1-羟基py葡糖醛酸外，from暴露蠕虫的组织样品的HPLC / F示踪还显示出三个额外的低强度峰，这些峰可能与基于相似激发/发射波长的to代谢有关。这些峰的强度都太低而无法被正确识别。在组织中的总PAH中，1-羟基py葡糖醛酸，1-羟基py和pyr分别占73％，2％和25％。通过鉴定肠液和排便水中的1-羟基py和1-羟基py葡糖醛酸苷来支持肠道代谢产物的消除。 1-羟基py是pyr的唯一Ⅰ相代谢产物，成为PAH暴露的有用标志物，可作为评估物种特异性PAH代谢能力的有价值的模型化合物。

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