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首页> 外文期刊>Environmental toxicology and chemistry >THE MISSING BIOMARKER LINK: RELATIONSHIPS BETWEEN EFFECTS ON THE CELLULAR ENERGY ALLOCATION BIOMARKER OF TOXIC ANT- STRESS ED DAPHNIA MAGNA AND CORRESPONDING POPULATION CHARACTERISTICS
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THE MISSING BIOMARKER LINK: RELATIONSHIPS BETWEEN EFFECTS ON THE CELLULAR ENERGY ALLOCATION BIOMARKER OF TOXIC ANT- STRESS ED DAPHNIA MAGNA AND CORRESPONDING POPULATION CHARACTERISTICS

机译：缺失的生物标志物链接：对有毒抗应力性蚤蚤细胞能量分配生物标志物的影响与相应的种群特征之间的关系

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The cellular energy allocation (CEA) methodology was used to assess the adverse effects of toxic stress on the energy budget of test organisms. This biochemical assay is quantified by determining changes in the available energy reserves, E_a (total carbohydrate, protein, and lipid content) and the energy consumption, E_c (electron transport activity). The CEA methodology was fully explored by using neonates of Daphnia magna exposed for 96 h to six model toxicants (CdCl_2, K_2Cr_2O_7, tributyltin chloride, linear alkylbenzene sulfonic acid, sodium pentachlorophenolate, and 2,4-dichlorophenoxyacetic acid). To evaluate the ecological relevance of the CEA parameter, we compared the suborganismal responses with population-level parameters (obtained from 21-d life-table experiments) such as the intrinsic rate of natural increase (r_m) and the mean total offspring per female. The observed reductions in CEA values were both the result of a decrease in E_a and an increase in E_c. From all individual CEA components analyzed, the lipid reserve criterion was the most sensitive endpoint studied. Both the CEA-based lowest-observed-adverse-effect concentration (LOAEC) values and the effective concentration of 10% (EC10) values were significantly (p < 0.05) and linearly correlated with the chronic (21-d) LOAEC and EC10 values based on growth, survival, and reproduction. This relationship demonstrates the usefulness of the methodology to predict long-term effects. Furthermore, significant (p < 0.0001) sigmoid relationships between the 96-h CEA value (expressed as percentage relative to the control) and population-level effects were observed.
机译：细胞能量分配（CEA）方法用于评估毒性应激对测试生物体能量收支的不利影响。通过确定可用能量储备E_a（总碳水化合物，蛋白质和脂质含量）和能量消耗E_c（电子传输活性）的变化来量化该生化测定。通过使用大型蚤（Daphnia magna）的新生儿暴露于六种模型毒物（CdCl_2，K_2Cr_2O_7，三丁基氯化锡，直链烷基苯磺酸，五氯苯酚钠和2,4-二氯苯氧基乙酸）96小时，来全面探索CEA方法。为了评估CEA参数的生态相关性，我们将亚有机体响应与人口水平参数（从21天寿命表实验获得）进行了比较，例如自然增长的内在率（r_m）和每位女性的平均总后代。观察到的CEA值降低是E_a降低和E_c升高的结果。从所有单独的CEA成分中分析，脂质储备标准是研究的最敏感的终点。基于CEA的最低观察到的不良反应浓度（LOAEC）值和10％的有效浓度（EC10）值均显着（p <0.05）并与慢性（21-d）LOAEC和EC10值线性相关基于生长，生存和繁殖。这种关系表明该方法可预测长期影响。此外，观察到96小时CEA值（相对于对照的百分数表示）与人群水平效应之间存在显着（p <0.0001）的S型关系。

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