QUANTITATIVE STRUCTURE―ACTIVITY RELATIONSHIPS FOR PREDICTING PERCUTANEOUS ABSORPTION RATES

JOHN D. WALKER; ROSEMARY RODFORD; GRACE PATLEWICZ

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QUANTITATIVE STRUCTURE―ACTIVITY RELATIONSHIPS FOR PREDICTING PERCUTANEOUS ABSORPTION RATES

机译：定量结构-活性关系用于预测瞬时吸收率

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Quantitative structure―activity relationships (QSARs) for predicting percutaneous absorption rates were reviewed. Overall progress has been hampered by the sparseness of good quality experimental data. A number of researchers have used the same data set to develop QSARs for predicting percutaneous absorption rates, a fact that makes it difficult, at this time, to recommend one or two QSARs for predicting percutaneous absorption rates. Identification of chemicals within domains of large chemical universes that should be tested to improve QSARs and the subsequent development of experimental percutaneous absorption rates for those chemicals will facilitate the development of more robust QSARs for predicting percutaneous absorption rates.

机译：定量结构-活性关系（QSARs）预测经皮吸收率进行了审查。高质量实验数据的稀疏性阻碍了总体进展。许多研究人员已经使用相同的数据集来开发QSAR来预测经皮吸收率，这一事实使得目前很难推荐一个或两个QSAR来预测经皮吸收率。在大型化学宇宙域内识别化学物质，应进行测试以改善QSAR，随后开发出针对这些化学物质的实验性经皮吸收速率，将有助于开发更强大的QSAR，以预测经皮吸收速率。

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来源
《Environmental toxicology and chemistry》 |2003年第8期|p.1870-1884|共15页
作者
JOHN D. WALKER; ROSEMARY RODFORD; GRACE PATLEWICZ;
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作者单位

TSCA Interagency Testing Committee, Office of Pollution Prevention and Toxics (7401), U.S. Environmental Protection Agency, 1200 Pennsylvania Avenue, Northwest, Washington, DC 20460;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类环境卫生、环境医学;毒物学（毒理学）;化学工业废物处理与综合利用;
关键词
quantitative structure―activity relationships permeability coefficient;

机译：定量结构－活性关系渗透系数;

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5. Integration of quantitative structure-activity relationships and ecological survivorship modeling to predict chronic toxicity to fish and amphibians. [D] . Spromberg, Julann Aline. 2002

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6. Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model [O] . Chris D. Edwards, Chris Luscombe, Peter Eddershaw, -1

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7. Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model [O] . 2016

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8. Development of Quantitative Structure-Activity Relationships for Predicting Biodegradation Kinetics [R] . Desai, S. M., Govind, R., Tabak, H. H. 1990

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QUANTITATIVE STRUCTURE―ACTIVITY RELATIONSHIPS FOR PREDICTING PERCUTANEOUS ABSORPTION RATES

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