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首页> 外文期刊>Environmental toxicology and chemistry >Hydroxylated and methylsulfone-containing metabolites of polychlorinated biphenyls in the plasma and blubber of bowhead whales (Balaena mysticetus).
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Hydroxylated and methylsulfone-containing metabolites of polychlorinated biphenyls in the plasma and blubber of bowhead whales (Balaena mysticetus).

机译：弓形鲸（Balaena mysticetus）的血浆和脂中多氯联苯的羟基化和含甲基砜的代谢产物。

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摘要

Bowhead whale (Balaena mysticetus) blubber (n = 20) and plasma (n = 19) samples were collected during the 1997 to 2000 Inuit subsistence harvests in Barrow, Alaska, USA, to quantify the concentrations of methylsulfone (MeSO2)-containing and hydroxylated (OH) polychlorinated biphenyl (PCB) metabolites in this cetacean. The distribution of MeSO2-PCBs in blubber was dominated by 4-MeSO2-substituted congeners, the most abundant being 4-MeSO2-CB-70, 3'-MeSO2-CB-132, and 4-MeSO2-CB-64. Mean (+/- 1 standard error) sum (sigma) MeSO2-PCBs concentrations in blubber were low (6.23 +/- 0.81 ng g(-1) lipid normalized) compared to concentrations previously reported in other marine mammals. However, similar ratios of MeSO2-PCB metabolites to parent PCB congeners among marine mammals suggest that cytochrome P450 2B-like biotransformation and other necessary enzyme-mediated processes and mechanisms that influence the formation and clearance of MeSO2-PCBs exist in the bowhead whale. Pentachlorophenol was the most abundant halogenated phenolic compound quantified in bowhead plasma (1.55 +/- 0.19 ng g(-1) wet wt). Despite indirect evidence for arene epoxidation of the biphenyl moiety inferred from MeSO2-PCB formation, sumOH-PCB concentrations in bowhead plasma were low (1.52 +/- 0.31 ng g(-1) wet wt) compared to humans and marine mammals and were comprised of only two detectable OH-PCB congeners (4'-OH-CB-130 and 4-OH-CB-187). Further research is required to elucidate the toxicokinetics and distribution of OH-PCBs in this cetacean.
机译：在美国阿拉斯加州巴罗市1997年至2000年因纽特人维持生计的收获期间收集了弓头鲸（Balaena mysticetus）脂肪（n = 20）和血浆（n = 19）样品，以量化含甲基砜（MeSO2）和羟基化的甲基砜的浓度（鲸鱼）中的（OH）多氯联苯（PCB）代谢产物。 MeSO2-PCBs在润滑脂中的分布以4-MeSO2-取代的同类物为主导，最丰富的是4-MeSO2-CB-70、3'-MeSO2-CB-132和4-MeSO2-CB-64。与先前在其他海洋哺乳动物中报告的浓度相比，润滑脂中的MeSO2-PCBs平均（+/- 1标准误差）总和（sigma）低（6.23 +/- 0.81 ng g（-1）脂质标准化）。然而，在海洋哺乳动物中，MeSO2-PCB代谢物与母体PCB同系物的比率相似，表明弓头鲸存在细胞色素P450 2B样生物转化以及其他影响MeSO2-PCBs形成和清除的酶介导的过程和机制。五氯苯酚是弓形血浆中定量最丰富的卤化酚类化合物（湿重1.55 +/- 0.19 ng g（-1））。尽管间接证据表明从MeSO2-PCB的形成可以推断出联苯部分的芳烃环氧化，但与人类和海洋哺乳动物相比，弓形血浆中sumOH-PCB的浓度仍较低（1.52 +/- 0.31 ng g（-1）湿重），且包含仅有两个可检测的OH-PCB同系物（4'-OH-CB-130和4-OH-CB-187）。需要进一步的研究以阐明该鲸类动物体内的OH-PCBs的毒代动力学和分布。

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