Utility of a Juvenile fathead minnow screening assay for detecting (Anti-) estrogenic substances

Grace H.Panter; Thomas H.Hutchinson; Reinhard Lange

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Utility of a Juvenile fathead minnow screening assay for detecting (Anti-) estrogenic substances

机译：少年黑头min鱼筛查测定法可用于检测（抗）雌激素物质

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The European Chemical Industry's aquatic research program for endocrine disrupters includes the development of an in vivo juvenile fathead minnow(Pimephales promelas) screening assay. Working within the Organization for Economic Cooperation and Development's (OECD, Paris, France) tiered approach to endocrine disrupter evaluation in fish, the juvenile fish screening protocol was adapted from the OECD test guideline 204. Six chemicals, with different (anti-)estrogenic potencies, were used to develop the in vivo juvenile fish screening protocol: diethylstilbestrol, 17α-ethynylestradiol genistein, methoxychlor, 4-tert-pen- tylphenol, and ZM189,154(a novel pharmaceutical antiestrogen).

机译：欧洲化学工业针对内分泌干扰物的水生研究计划包括开发体内的幼年fat鱼（Pimephales promelas）筛选测定法。在经济合作与发展组织（经合组织，法国巴黎）对鱼类内分泌干扰物评估的分层方法中，根据《经合组织测试准则》 204改编了幼鱼筛选方案。六种化学物质，具有不同的（抗雌激素性）效力，用于开发体内幼鱼筛选方案：己烯雌酚，17α-乙炔雌二醇染料木黄酮，甲氧基氯，4-叔戊基苯酚和ZM189,154（新型抗雌激素药）。

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来源
《Environmental toxicology and chemistry》 |2002年第2期|p.319-326|共8页
作者
Grace H.Panter; Thomas H.Hutchinson; Reinhard Lange;
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作者单位

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类环境卫生、环境医学;毒物学（毒理学）;化学工业废物处理与综合利用;
关键词
Screen; Fathead minnow; (Anti-)estrogenic; Vitellogenin;

机译：屏幕;胖头min鱼;（抗雌激素）;卵黄蛋白原;

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7. Estrogen in the Water: Impacts of Sewage Wastewater on Feminization and Vitellogenin Expression in Male Fathead Minnows (Pimephales promelas) [O] . Butler, Lexis 2012

机译：水中的雌激素：污水对雄性黑头Min（Pimephales promelas）中女性化和卵黄蛋白原表达的影响
8. Results of a Screening Test on Acute Toxicity in Fathead Minnow (Pimephales promelas) with Dinitrile (Substance A) and (Substance B) [R] . 2008

机译：使用二腈（物质a）和（物质B）对Fathead minnow（pimephales promelas）急性毒性进行筛选试验的结果

Utility of a Juvenile fathead minnow screening assay for detecting (Anti-) estrogenic substances

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