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首页> 外文期刊>Environmental toxicology and chemistry >Inhibition of digestive enzyme activities by copper in the guts of various marine benthic invertebrates
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Inhibition of digestive enzyme activities by copper in the guts of various marine benthic invertebrates

机译：铜对各种海洋底栖无脊椎动物内脏的消化酶活性的抑制作用

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摘要

Digestive systems of deposit and suspension feeders can be exposed to high concentrations of copper (Cu) by ingestion of contaminated sediments. We assessed a potential impact of this Cu exposure on digestive enzyme activities in a wide range of benthic organisms by monitoring enzyme activities in their gut fluids during in vitro titrations with dissolved Cu, with mimics Cu solubilization from sediments. Increasing Cu inhibited digestive protease activities at threshold values, which varied widely Among organisms, from 8μM for an echinoderm to 0.4 M for an echiuran. More Cu was required to inhibit proteases in guts Containing higher amino acid concentrations because strong Cu-binding sites on amino acids prevent Cu interaction with the Enzymatically active sites.
机译：沉积物和悬浮物进料器的消化系统可能会因摄入受污染的沉积物而暴露于高浓度的铜（Cu）中。我们通过监测溶解铜的体外滴定期间的铜消化液中酶的活性，并模拟铜从沉积物中的增溶作用，评估了这种铜暴露对广泛底栖生物中消化酶活性的潜在影响。铜的增加抑制了其阈值的消化蛋白酶活性，该阈值在生物体中差异很大，从棘皮动物的8μM到鱼鳞茎的0.4M。抑制更高浓度氨基酸的肠道中的蛋白酶需要更多的Cu，因为氨基酸上的强Cu结合位点会阻止Cu与酶活性位点的相互作用。

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