POTENTIAL MULTIDRUG RESISTANCE GENE POHL: AN ECOLOGICALLY RELEVANT INDICATOR IN MARINE SPONGES

Anatoli Krasko; Branko Kurelec; Renato Batel

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POTENTIAL MULTIDRUG RESISTANCE GENE POHL: AN ECOLOGICALLY RELEVANT INDICATOR IN MARINE SPONGES

机译：潜在的多药耐药基因POHL：海洋海绵中与生态相关的指标

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Sponges are sessile filter feeders found in all aquatic habitats from the tropics to the arctic. Against potential environmental hazards, they are provided with efficient defense systems, e.g., protecting and/or the P-170/multidrug resistance pump system. Here we report on a further multidrug resistance pathway that is related to the pad one homologue(POH1)mechanism recently identified in humans. It is suggested that proteolysis is involved in the inactivation of xenobiotics by the POH1 system.

机译：海绵是从热带到北极的所有水生生境中发现的无柄滤食性动物。针对潜在的环境危害，他们配备了有效的防御系统，例如保护和/或P-170 /耐多药泵系统。在这里，我们报告了进一步的多药耐药途径，该途径与最近在人体中发现的一种垫（POH1）机制有关。提示蛋白水解参与了POH1系统对异生物素的灭活作用。

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来源
《Environmental toxicology and chemistry》 |2001年第1期|p.198-204|共7页
作者
Anatoli Krasko; Branko Kurelec; Renato Batel;
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作者单位

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类环境卫生、环境医学;毒物学（毒理学）;化学工业废物处理与综合利用;
关键词
Multidrug resistance; Northern Adriatic; POHL gene expression;

机译：多药耐药性;亚得里亚海北部;POHL基因表达;

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机译：生态相关的抗逆性：从微阵列和数量性状基因座到候选基因-以果蝇为模型生物并以气候和遗传胁迫为模型胁迫的研究计划和初步结果
2. Ecologically relevant stress resistance: from microarrays and quantitative trait loci to candidate genes a€“ A research plan and preliminary results using Drosophila as a model organism and climatic and genetic stress as model stresses [J] . Jesper G S??rensen, Torsten N Kristensen, Volker Loeschcke1 Journal of biosciences . 2004,第4期

机译：与生态相关的抗逆性：从微阵列和数量性状基因座到候选基因-以果蝇为模型生物，以气候和遗传胁迫为模型胁迫的研究计划和初步结果
3. Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells. [J] . Abraham I, Jain S, Wu CP, Biochemical Pharmacology . 2010,第10期

机译：海洋海绵衍生的七氟醚三萜类化合物可逆转癌细胞中的P-糖蛋白（ABCB1）介导的多药耐药性。
4. Cloning of Disease Resistance-relevant Nramp and MHC IIB Genes and their Application Potential in Molecular Breeding for Disease Resistance in Japanese Flounder (Paralichthys olivaceus) [C] . . 2005

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5. Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells [D] . Abraham, Ioana 2012

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6. Reporter Dyes Demonstrate Functional Expression of Multidrug Resistance Proteins in the Marine Flatworm Macrostomum lignano: The Sponge-Derived Dye Ageladine A Is Not a Substrate of These Transporters [O] . Kristin Tietje, Georgina Rivera-Ingraham, Charlotte Petters, 2013

机译：记者染料证明了海洋扁虫Macrostomum lignano中多药耐药蛋白的功能性表达：海绵衍生的染料Ageladine A不是这些转运蛋白的底物
7. Reporter Dyes Demonstrate Functional Expression of Multidrug Resistance Proteins in the Marine Flatworm Macrostomum lignano: The Sponge-Derived Dye Ageladine A Is Not a Substrate of These Transporters [O] . Ulf Bickmeyer, Ralf Dringen, Charlotte Petters, 2013

机译：报告染料显示海洋扁虫macrostomum lignano中多药耐药蛋白的功能性表达：海绵衍生的染料ageladine a不是这些转运蛋白的底物

POTENTIAL MULTIDRUG RESISTANCE GENE POHL: AN ECOLOGICALLY RELEVANT INDICATOR IN MARINE SPONGES

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