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首页> 外文期刊>Environmental toxicology and chemistry >EFFECT OF BILE SALTS, LIPID, AND HUMIC ACIDS ON ABSORPTION OF BENZO[a]PYRENE BY ISOLATED CHANNEL CATFISH(ICTALURUS PUNCTATUS) INTESTINE SEGMENTS
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EFFECT OF BILE SALTS, LIPID, AND HUMIC ACIDS ON ABSORPTION OF BENZO[a]PYRENE BY ISOLATED CHANNEL CATFISH(ICTALURUS PUNCTATUS) INTESTINE SEGMENTS

机译:胆汁盐,脂类和腐殖酸对分离通道牛磺酸(ICTALURUS PUNCTATUS)肠段吸收苯并[a] P的影响

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摘要

Dietary absorption of lipophilic contaminants may be a significant of exposure in aquatic organisms. Bile salts, lipids, and humic acids are important factors that may influence the intestinal absorption of a contaminant such as benzo[a]pyrene (BaP). We hypothesized that bile salts, monoglycerides, and free fatty acids would increase BaP intestinal absorption, while triglycerides, humic acids, and sediment would decrease BaP intestinal absorption. We have established and validated an in vitro model to examine modification of ~3H-BaP absorption in everted intestinal segments from channel catfish(Ictalurus punctatus).
机译:饮食中脂溶性污染物的吸收可能是水生生物暴露的重要原因。胆汁盐,脂质和腐殖酸是可能影响诸如苯并[a]((BaP)之类的污染物在肠道中吸收的重要因素。我们假设胆汁盐,甘油单酸酯和游离脂肪酸会增加BaP的肠道吸收,而甘油三酸酯,腐殖酸和沉淀物会降低BaP的肠道吸收。我们已经建立并验证了体外模型,以检查通道channel鱼(Ictalurus punctatus)外翻肠段中〜3H-BaP吸收的修饰。

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