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首页> 外文期刊>Environmental toxicology and chemistry >EVALUAfION OF PLANAR HALOGENAfED AND POLYCYCLIC AROMAfIC HYDROCARBONS IN ESTUARINE SEDIMENTS USING ETHOXYRESORUFIN- O-DEETHYLASE lNDUCTION OF H4IIE CELLS
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EVALUAfION OF PLANAR HALOGENAfED AND POLYCYCLIC AROMAfIC HYDROCARBONS IN ESTUARINE SEDIMENTS USING ETHOXYRESORUFIN- O-DEETHYLASE lNDUCTION OF H4IIE CELLS

机译：H4IIE细胞的乙二醛-异戊二烯-O-脱氧酶引诱法评价口水沉积物中的平面卤代和多环芳烃

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Polycyclic aromatic hydrocarbons (PAHs) and planar halogenated hydrocarbons (PHHs), including polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs) were determined in fractionated sediment extracts from the Hudson-Raritan estuary and Newark Bay, New Jersey, USA, as part of a comprehensive risk assessment. Contributions of PCDDs/PCDFs, PCBs, and PAHs to the total toxic equivalents (TEQs) were measured using an H4IIE bioassay and calculated from instrumentally determined concentrations using international toxic equivalency factors. Th. H4IIE TEQs of whole and frac- tionated extracts were compared to calcuIated TEQs to investigate the applicability of the bioassay approach for evaluating 7- ethoxyresorufin-O--deethylease induction by PHHs and PAHs present together in complex mixtures. Although 2,3,7,8-tetrachloro- dibenzo-p-dioxin contributed from 4l to 79 of the calculated TEQs from PCDDs/PCDFs and planar PCBs in all sediments sampled, the PAH-containing fractions accounted for to >80 of the total TEQs determined either instrumentally or by bioassay. Calculated TEQs from PAHs, based on reported toxic equivalency factors for only seven PAHs, were severalfOld greater than the bioassay- derived TEQs of PAH-only fractions of the sediment extracts. Significant correlations were observed between bioassay and in- strumentally determined toxic equivalents in the more purified fractions but not in fractions only purified by size-exclusion or argentate chromatographies alone.
机译：在Hudson-Raritan河口和纽瓦克湾的分馏沉积物中，测定了多环芳烃（PAH）和平面卤代烃（PHH），包括多氯二苯并对二恶英（PCDD），二苯并呋喃（PCDF）和联苯（PCB）。 ，作为美国综合风险评估的一部分。使用H4IIE生物测定法测量PCDD / PCDF，PCB和PAH对总毒性当量（TEQ）的贡献，并使用国际毒性当量因子从仪器确定的浓度进行计算。 。将完整提取物和破碎提取物的H4IIE TEQ与计算出的TEQ进行比较，以研究生物测定方法对复杂混合物中同时存在的PHHs和PAHs诱导7-乙氧基间苯二酚-O-脱乙基酶的评价。尽管在所有采样的沉积物中，PCDDs / PCDFs和平面多氯联苯中的2,3,7,8-四氯二苯并-p-二恶英占TEL的4l至79，但多环芳烃占PAH总量的80％以上通过仪器或通过生物测定确定的TEQ。根据仅报告的七个PAH的毒性当量因子，从PAHs计算出的TEQ数比沉淀物提取物中仅PAH馏分的生物测定衍生的TEQs高出几倍。在更高纯度的馏分中，生物测定与仪器测定的毒性当量之间存在显着的相关性，而在仅通过大小排阻色谱法或纯银色谱法纯化的馏分中则未发现。

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