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首页> 外文期刊>Environmental toxicology and chemistry >PHYSIOLOGICAL MEASURES OF NEUROTOXICITY OF DIAZINON AND MALATHION TO LARVAL RAINBOW TROUT (ONCORHYNCHUS MYKISS) AND THEIR CORRELATION WITH BEHAVIORAL MEASURES
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PHYSIOLOGICAL MEASURES OF NEUROTOXICITY OF DIAZINON AND MALATHION TO LARVAL RAINBOW TROUT (ONCORHYNCHUS MYKISS) AND THEIR CORRELATION WITH BEHAVIORAL MEASURES

机译：叠氮酮和马拉硫磷对幼体虹鳟鱼神经毒性的生理措施及其与行为措施的相关性

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Relations between neurotoxicants and changes in physiological parameters and behavior were investigated in larval rainbow trout (RBT; Oncorhynchus mykiss) exposed to sublethal concentrations of two organophosphate pesticides (OPs). Fish were exposed to diazinon and malathion in static-renewal experiments. After exposures for 24, 96, or 96 h, followed by 48 h of recovery, individual RBT were videotaped to assess locomotory behaviors. Brain tissue from the same fish was assayed for the physiological endpoints, cholinesterase (ChE) activity, muscarinic cholinergic receptor (MChR) number (B_max), and MChR affinity (K_D). Cholinesterase activity decreased significantly with increasing concentrations of both diazinon and malathion and differed significantly among exposure durations, with 24- and 96-h means less than 48-h recovery means. Decreases in B_max with OP concentration were not significant for either chemical, and K_D was unaffected. Changes in swimming speed and distance were significantly correlated with changes in ChE activity for both chemicals; rate of turning was significantly correlated with ChE activity in malathion exposures. These results suggest that correlations between physiological and behavioral changes previously seen in mammals also occur in fish.
机译：研究了暴露于亚致死浓度的两种有机磷农药（OPs）的幼体虹鳟鱼（RBT； Oncorhynchus mykiss）中神经毒性与生理参数和行为变化之间的关系。在静态更新实验中，将鱼暴露于二嗪农和马拉硫磷中。暴露24、96或96小时，然后恢复48小时后，对每个RBT进行录像以评估运动行为。分析了来自同一条鱼的脑组织的生理终点，胆碱酯酶（ChE）活性，毒蕈碱胆碱能受体（MChR）数（B_max）和MChR亲和力（K_D）。胆碱酯酶活性随二嗪农和马拉硫磷浓度的增加而显着降低，并且在暴露持续时间之间存在显着差异，其中24小时和96小时的恢复时间少于48小时。两种化学品中，OP浓度下B_max的降低均不显着，并且K_D不受影响。两种化学物质的游泳速度和距离变化均与ChE活性变化显着相关。在马拉硫磷暴露中，翻身率与ChE活性显着相关。这些结果表明，以前在哺乳动物中看到的生理变化和行为变化之间的相关性也发生在鱼类中。

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