EFFECTS OF POLYCYCLIC AROMATIC HYDROCARBONS ON EXPRESSION OF CYP1A IN SALMON(SALMO SALAR)FOLLOWING EXPERIMENTAL EXPOSURE AND AFTER THE BRAER OIL SPILL

Ronald M.Stagg; Jan Rusin; Mary E.McPhail

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EFFECTS OF POLYCYCLIC AROMATIC HYDROCARBONS ON EXPRESSION OF CYP1A IN SALMON(SALMO SALAR)FOLLOWING EXPERIMENTAL EXPOSURE AND AFTER THE BRAER OIL SPILL

机译：实验性暴露和溴油溢流后多环芳烃对鲑鱼（鲑鱼）中CYP1A表达的影响

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The induction of hepatic CYP1A by selected polycyclic aromatic hydrocarbons(PAHs)was followed in Atlantic salmon (Salmo salar)by measurement of CYP1A messenger RNA(Mrna), CYP1A protein levels, and catalytically by the measurement of 7-ethoxyresorufin-O-deethylase activity. There was clear correspondence between all three methods of measurement both in terms of the specificity of response of five-and some four-ring PAHs and in terms of the dose-response relationship to methyl- cholanthrene.

机译：随后通过测量CYP1A信使RNA（Mrna），CYP1A的蛋白水平并通过催化测量7-乙氧基异色质素-O-脱乙基酶的活性，在大西洋鲑（Salmo salar）中诱导了由选定的多环芳烃（PAHs）诱导的肝CYP1A的合成。。在五环和一些四环PAHs的反应特异性以及对甲基胆蒽的剂量反应关系方面，这三种测量方法之间都存在明显的对应关系。

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来源
《Environmental toxicology and chemistry》 |2000年第11期|p.2797-2805|共9页
作者
Ronald M.Stagg; Jan Rusin; Mary E.McPhail;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类环境卫生、环境医学;毒物学（毒理学）;化学工业废物处理与综合利用;
关键词
CYP1A; Expression; Salmon;

机译：CYP1A;表达;三文鱼;

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EFFECTS OF POLYCYCLIC AROMATIC HYDROCARBONS ON EXPRESSION OF CYP1A IN SALMON(SALMO SALAR)FOLLOWING EXPERIMENTAL EXPOSURE AND AFTER THE BRAER OIL SPILL

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