...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental toxicology and chemistry >MEMBRANE BURDENS OF CHLORINATED BENZENES LOWER THE MAIN PHASE TRANSITION TEMPERATURE IN DIPALMITOYL-PHOSPHATIDYLCHOLINE VESICLES: IMPLICATIONS FOR TOXICITY BY NARCOTIC CHEMICALS
【24h】

MEMBRANE BURDENS OF CHLORINATED BENZENES LOWER THE MAIN PHASE TRANSITION TEMPERATURE IN DIPALMITOYL-PHOSPHATIDYLCHOLINE VESICLES: IMPLICATIONS FOR TOXICITY BY NARCOTIC CHEMICALS

机译：苯二甲酰-磷脂酰胆碱中主要相变温度较低时氯化苯的膜突物：对麻醉药品的毒性影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the membrane of an organism that dies due to exposure to narcotic chemicals, the main phase transition temperature (T_(tr)) of the phospholipids is decreased and the fluidity is increased. The decrease in T_(tr) depends on the molar concentration of narcotics in the membrane (membrane burden) and is irrespective of the physicochemical properties of the chemicals. If membrane-water partition coefficients, exposure concentrations, and the amount of lipid in the system are known, membrane burdens of narcotic chemicals can be calculated and compared to membrane burdens that yield toxicity. The partition coefficients of a series of chlorobenzenes between phospholipid vesicles and water (K_(mw)) were measured at different temperatures in a new experimental set-up. K_(mw)'s were higher in the liquid-crystalline phase than in the gel phase. Partitioning into the gel phase was entropy driven, partitioning into the liquid-crystalline phase was driven by entropy and enthalpy. The fluidity change in phospholipid vesicles, after accumulation of chlorobenzenes, was measured from the change in T_(tr). The membrane burdens of various chlorobenzenes needed for a lowering of T_(tr) were comparable (e.g., 20—60 mmol/kg for a decrease of 1.0℃). The membrane burden needed in vivo for lethality by narcotic chemicals such as chlorobenzenes was calculated to be 40-160 mmol/kg membrane. By combining the in vivo and in vitro data, it can be concluded that in organisms that die due to exposure to narcotic chemicals, the fluidity of the membrane is increased.
机译：在因暴露于麻醉性化学而死亡的生物的膜中，磷脂的主相变温度（T_（tr））降低，流动性增加。 T_（tr）的降低取决于膜中麻醉剂的摩尔浓度（膜负荷），并且与化学物质的物理化学性质无关。如果已知膜水分配系数，暴露浓度和系统中脂质的量，则可以计算麻醉药品的膜负荷并将其与产生毒性的膜负荷进行比较。在一个新的实验装置中，在不同温度下测量了一系列氯苯在磷脂囊泡和水之间的分配系数（K_（mw））。液晶相中的K_（mw）高于凝胶相中的K_（mw）。划分成凝胶相是由熵驱动的，划分成液晶相是由熵和焓驱动的。由T_（tr）的变化测量氯苯积累后磷脂囊泡的流动性变化。降低T_（tr）所需的各种氯苯的膜负荷是可比的（例如，降低1.0℃时为20-60 mmol / kg）。麻醉性化学品（如氯苯）致死所需的体内膜负荷经计算为40-160 mmol / kg膜。通过结合体内和体外数据，可以得出结论，在由于暴露于麻醉化学而死亡的生物中，膜的流动性增加了。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号