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首页> 外文期刊>Environmental toxicology and chemistry >USE OF JOINT TOXIC RESPONSE TO DEFINE THE PRIMARY MODE OF TOXIC ACTION FOR DIVERSE INDUSTRIAL ORGANIC CHEMICALS
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USE OF JOINT TOXIC RESPONSE TO DEFINE THE PRIMARY MODE OF TOXIC ACTION FOR DIVERSE INDUSTRIAL ORGANIC CHEMICALS

机译：使用联合毒性反应来确定多种工业有机化学品的主要作用方式

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An important aspect of understanding how multiple toxicants jointly act involves defining the primary mode of toxic action for the chemicals of interest. We have explored the use of 96-h acute toxicity tests with juvenile fathead minnows and primarily binary chemical mixtures to define the primary acute mode of toxic action for diverse industrial organic chemicals. Our investigation mainly considered the two special cases of noninteractive joint action known as concentration (simple similar) and response (independent) addition. The different forms of joint toxicity with binary mixtures were graphically illustrated by isobole diagrams. Designated as the mode of action-specific reference toxicants were 1-octanol, phenol, and 2,4-dinitrophenol. It was observed from binary isobole diagrams that a chemical with a similar primary mode of toxic action to that of a reference toxicant would display a concentration-addition type of joint action with the reference toxicant over the entire mixture ratio range. Dissimilar chemicals with very steep concentration-response curves generally showed an interaction that was less-than-concentration additive, but consistently demonstrated a joint toxicity that was greater than predicted by the response-addition model. The more-than-concentration additive and complex isoboles that are indicative of interactive toxicity were not commonly observed in our experiments.
机译：了解多种毒物如何共同起作用的一个重要方面涉及为目标化学物质定义主要的毒作用模式。我们探索了将96h急性毒性试验与幼年黑头min鱼以及主要的二元化学混合物一起使用，以确定各种工业有机化学品的主要急性毒性作用模式。我们的研究主要考虑了两个非交互联合作用的特殊情况，即集中（简单相似）和响应（独立）加法。用等边线图图解说明了二元混合物对关节的不同形式的毒性作用。指定为特定作用方式的参考毒物为1-辛醇，苯酚和2,4-二硝基苯酚。从二元等油线图观察到，具有与参考有毒物质相似的主要毒理作用模式的化学药品在整个混合比范围内，将显示出与参考有毒物质的浓度加合型联合作用。具有非常陡峭的浓度-响应曲线的异种化学品通常显示出一种相互作用，该相互作用小于浓度添加剂，但始终显示出大于响应-添加模型所预测的联合毒性。在我们的实验中，通常没有观察到超过浓度的添加剂和复杂的异构体，它们表明了相互作用的毒性。

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