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首页> 外文期刊>Environmental toxicology and chemistry >IMMUNOPATHOLOGY OF 8-WEEK-OLD RING-NECKED PHEASANTS (PHASIANUS COLCHICUS) EXPOSED TO MALATHION
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IMMUNOPATHOLOGY OF 8-WEEK-OLD RING-NECKED PHEASANTS (PHASIANUS COLCHICUS) EXPOSED TO MALATHION

机译：暴露于马拉硫磷的8周龄环颈锦鸡（PHASIANUS COLCHICUS）的免疫病理学

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In addition to their acute neurotoxic effects, some organophosphorus compounds have been shown to have immu-notoxic properties. Alterations in the immune system may lead to chronic morbidity and/or mortality that is not readily apparent at the time of initial exposure. Because it often inhabits land that is intensely farmed, the ring-necked pheasant (Phasianus colchicus) may be a suitable biomonitor of agroecosy stems, especially those used in the production of corn. We examined im-munopathologic effects of a widely used organophosphate insecticide, malathion, on 8-week-old, cage-reared ring-necked pheasants 3 d after a single oral dose. No differences were seen in hematologic parameters, body weight, or weight of the bursa of Fabricius. Birds given a high dose of malathion (230 mg/kg) displayed significant decreases in absolute and relative thymic and splenic weights (p ≤ 0.05). Significant changes were also seen in thymic and splenic histomorphometry (p ≤ 0.05). The high-dose group and, in some cases, the low-dose group (92 mg/kg) displayed significant histologic lesions. These findings indicate that a single dose of malathion, at the LD50 level (230 mg/kg) and occasionally at 40% of the LD50 level (92 mg/kg), is capable of inducing quantitative and qualitative changes in the lymphoid organs of the ring-necked pheasant that may affect immune function.
机译：除其急性神经毒性作用外，某些有机磷化合物已显示具有免疫毒性。免疫系统的改变可能导致慢性发病和/或死亡，这在初次接触时尚不明显。由于环颈野鸡（Phasianus colchicus）经常居住在集约化耕种的土地上，因此可能是合适的农业生态茎生物监控器，尤其是用于玉米生产的生物监测器。我们研究了一种广泛使用的有机磷酸盐杀虫剂马拉硫磷对单周口服3天后8周龄，笼养的环颈野鸡的免疫病理作用。在血液学参数，体重或法氏囊的法氏囊重量方面未见差异。给予高剂量马拉硫磷（230 mg / kg）的家禽的胸腺和绝对胸腺重量和相对体重显着下降（p≤0.05）。胸腺和脾脏组织形态学测量也观察到显着变化（p≤0.05）。高剂量组以及某些情况下的低剂量组（92 mg / kg）表现出明显的组织学损害。这些发现表明，单剂量马拉硫磷在LD50水平（230 mg / kg）且偶尔在LD50水平的40％（92 mg / kg）时，能够诱导小鼠淋巴器官的数量和质量变化。可能会影响免疫功能的环颈山鸡。

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