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首页> 外文期刊>Environmental toxicology and chemistry >Investigating the Fate of Copper in a Laboratory-Based Toxicity Test with Embryos of Mytilus galloprovincialis: Copper Mass Balance of a Closed Bioassay
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Investigating the Fate of Copper in a Laboratory-Based Toxicity Test with Embryos of Mytilus galloprovincialis: Copper Mass Balance of a Closed Bioassay

机译：用髓病毒胆素胚胎的实验室毒性试验中调查铜的命运：闭合生物测定的铜质量平衡

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The production of accurate and reliable data on metal toxicity during ecotoxicological bioassays is important for credible environmental risk assessments and management in aquatic environments. Actual measurements and reporting of contaminant concentrations in bioassays are, however, often disregarded; and potential contaminant loss attributable to adsorption processes (e.g., wall adsorption) in bioassays is widely omitted, which can have detrimental effects on calculated metal toxicity thresholds. In the present we assessed copper (Cu) mass balance during a standard 48-h bioassay test with blue mussel (Mytilus galloprovincialis) embryos to evaluate effects on calculated toxicity endpoints. We demonstrated that measured Cu concentrations at the test conclusion need to be used to quantify the risk of Cu toxicity because nominal Cu and initial Cu concentrations underestimate overall Cu toxicity by up to 1.5-fold, owing to Cu loss in solution attributable to adsorption and bioaccumulation processes. For the first time we provide evidence that extracellular adsorption to the biological surface of the embryos is the most important sink for total dissolved Cu in a bioassay. We also established that adsorbed extracellular Cu accumulation reduces Cu toxicity to embryos, potentially by inhibiting Cu from entering the cell of the mussel embryo. Environmental factors (e.g., salinity and dissolved organic carbon) did not influence the partitioning of Cu within the laboratory-based bioassay. The present results 1) demonstrate the importance of differentiating extra- and intracellular Cu pools to improve our understanding of Cu toxicity and associated processes, 2) reveal the potential for bias with respect to calculated Cu toxicity thresholds when results are based on nominal and initial Cu concentrations, and 3) point out the need to follow current guidelines for the testing of chemicals to standardize toxicity tests and data reporting. Environ Toxicol Chem 2019;38:561-574. (c) 2019 SETAC
机译：在生态毒理学生物测定中生产准确可靠的金属毒性数据对于水生环境中可信的环境风险评估和管理是重要的。然而，生物测定中的实际测量和报告污染物浓度通常忽略;广泛省略了对生物测定中吸附过程（例如，壁吸附）可归因的污染物损失，这可能对计算的金属毒性阈值具有不利影响。在本发明中，我们评估了在标准的48-H生物测定试验期间的铜（Cu）质量平衡，其中蓝贻贝（肉豆蔻血液incialis）胚胎评估对计算毒性终点的影响。我们证明了测试结论中的测量Cu浓度需要用于量化Cu毒性的风险，因为由于溶解和生物累积的溶液中的Cu损失，标称Cu和初始Cu浓度低至1.5倍，因此官方Cu和初始Cu浓度高达1.5倍流程。我们首次提供证据表明对胚胎的生物表面的细胞外吸附是生物测定中总溶解的Cu的最重要的水槽。我们还确定吸附的细胞外Cu累积将Cu毒性降低到胚胎中，可能通过抑制贻贝胚胎的细胞来抑制Cu。环境因素（例如，盐度和溶解的有机碳）没有影响基于实验室的生物测定中Cu的分配。目前的结果1）证明了区分细胞和细胞内Cu池以改善我们对Cu毒性和相关过程的理解，2）在结果基于标称和初始Cu时，揭示了在计算出的Cu毒性阈值方面的偏差潜力3）浓度和3）指出需要遵循现有指南的化学品测试，以标准化毒性测试和数据报告。环境毒素科学2019; 38：561-574。 （c）2019 Setac

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