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首页> 外文期刊>Environmental toxicology and chemistry >Human and Aquatic Toxicity Potential of Petroleum Biodegradation Metabolite Mixtures in Groundwater from Fuel Release Sites
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Human and Aquatic Toxicity Potential of Petroleum Biodegradation Metabolite Mixtures in Groundwater from Fuel Release Sites

机译：从燃料释放位点的地下水中石油生物降解代谢物混合物的人和水生毒性潜力

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The potential toxicity to human and aquatic receptors of petroleum fuel biodegradation metabolites (oxygen-containing organic compounds [OCOCs]) in groundwater has been investigated as part of a multi-year research program. Whole mixtures collected from locations upgradient and downgradient of multiple fuel release sites were tested using: 1) in vitro screening assays for human genotoxicity (the gamma-H2AX assay) and estrogenic effects (estrogen receptor transcriptional activation assay), and 2) chronic aquatic toxicity tests in 3 species (Ceriodaphnia dubia,Raphidocelis subcapitata, andPimephales promelas). In vitro screening assay results demonstrated that the mixtures did not cause genotoxic or estrogenic effects. No OCOC-related aquatic toxicity was observed and when aquatic toxicity did occur, upgradient samples typically had the same response as samples downgradient of the release, indicating that background water quality was impacting the results. This information provides additional support for previous work that focused on the individual compounds and, taken together, indicates that OCOCs from petroleum degradation at fuel release sites are unlikely to cause toxicity to human or freshwater receptors at the concentrations present.Environ Toxicol Chem2020;00:1-12. (c) 2020 The Authors.Environmental Toxicology and Chemistrypublished by Wiley Periodicals LLC on behalf of SETAC.
机译：作为多年研究计划的一部分，已经研究了地下水中石油燃料生物降解代谢物（含氧有机化合物[OCOCS]）对石油燃料生物降解代谢物（含氧有机化合物[ococs]）的潜在毒性。使用以下燃料释放位点收集的全部混合物使用：1）用于人类遗传毒性（γ-H2AX测定）和雌激素作用（雌激素受体转录激活测定）和2）慢性水生毒性的体外筛选测定在3种（Ceriodaphnia Dubia，Raphidocelis Subcapitata，Andpimephales Promelas）中的测试。体外筛选测定结果表明，混合物没有引起遗传毒性或雌激素作用。没有观察到ococ相关的水生毒性，当发生水生毒性时，升级样本通常与样品的释放降级相同，表明背景水质正在影响结果。该信息为以前的工作提供了额外的支持，该工作集中在各种化合物上，并将其携带在一起，表明来自燃料释放位点的石油降解的OCOC不太可能在浓度的浓度下对人或淡水受体引起毒性.ENVIRON毒素Chem20202020202020; 00： 1-12。 （c）2020作者。由于Wiley期刊LLC代表Setac的环境和化学毒理学和化学毒理学。

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