...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental toxicology and chemistry >Predicting Early Life Stage Mortality in Birds and Fishes from Exposure to Low‐Potency Agonists of the Aryl Hydrocarbon Receptor: A Cross‐Species Quantitative Adverse Outcome Pathway Approach
【24h】

Predicting Early Life Stage Mortality in Birds and Fishes from Exposure to Low‐Potency Agonists of the Aryl Hydrocarbon Receptor: A Cross‐Species Quantitative Adverse Outcome Pathway Approach

机译：从芳基烃受体的低效力激动剂暴露于鸟类和鱼类中的早期生命阶段死亡率：一种跨物种定量不良结果途径方法

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dioxin-like compounds (DLCs) cause early life stage mortality of vertebrates through activation of the aryl hydrocarbon receptor (AhR). A prior study developed a cross-species quantitative adverse outcome pathway (qAOP) which can predict full dose-response curves of early life stage mortality for any species of bird or fish exposed to DLCs using the species- and chemical-specific 50% effect concentration (EC50) from an in vitro AhR transactivation assay with COS-7 cells. However, calculating a reliable EC50 for input into this qAOP requires the maximal response of the concentration-response curve to be known, which is not always possible for low-potency agonists, such as some polychlorinated biphenyls (PCBs). To enable predictions for these low-potency agonists, the present study revised this qAOP to use the effect concentration threshold (ECThreshold) from the in vitro AhR transactivation assay as input. Significant linear relationships were demonstrated between EC(Threshold)and the dose to cause 0, 10, 50, or 100% mortality among early life stages of 3 species of birds and 7 species of fish for 4 DLCs: 2,3,7,8-tetrachlorodibenzo-p-dioxin, PCB 126, PCB 77, and PCB 105. These 4 linear relationships were combined to form the revised qAOP. This qAOP using the EC(Threshold)enables prediction of experimental dose-response curves for lower-potency agonists to within an order of magnitude on average, but the prior qAOP using EC50 predicts experimental dose-response curves for higher-potency agonists with greater accuracy.Environ Toxicol Chem2020;00:1-10. (c) 2020 SETAC
机译：二恶英的化合物（DLC）通过激活芳基烃受体（AHR）导致脊椎动物的早期寿命阶段死亡率。先前的研究开发了一种跨物种的定量不良结果途径（QAOP），其可以使用物种和化学特异性50％效应浓度预测任何暴露于DLC的鸟类或鱼类的初期死亡率的全剂量 - 反应曲线（EC50）由含COS-7细胞的体外AHR转移激活测定法。然而，计算用于输入的可靠EC50，需要浓度 - 响应曲线的最大响应是已知的，这对于低效力激动剂（例如一些多氯联苯（PCB）而言并不总是可能。为了使这些低效力激动剂的预测，本研究修正了这种QAOP以使用来自体外AHR转移试剂测定的效果浓度阈值（Ecthreshold）作为输入。 EC（阈值）和剂量在3种鸟类和7种鱼类的早期生命阶段之间的死亡率进行了显着的线性关系，为4种DLC的7种鱼类，2,3,7,8 -tetroThlorodibenzo-p-Dioxin，PCB 126，PCB 77和PCB 105.这些4线性关系被组合以形成修订的QAOP。使用EC（阈值）的这种QaOP使得能够平均预测低效力激动剂的实验剂量 - 反应曲线，但使用EC50的先前QAOP预测高效激动剂的实验剂量 - 反应曲线更高的准确性.Environ毒素Chem2020; 00：1-10。 （c）2020 Setac

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号