...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental toxicology and chemistry >Exploring the Concepts of Concentration Addition and Independent Action Using a Linear Low-Effect Mixture Model
【24h】

Exploring the Concepts of Concentration Addition and Independent Action Using a Linear Low-Effect Mixture Model

机译：使用线性低效应混合模型探索集中加法和独立行动的概念

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chemicals emitted into the environment are typically present at low concentrations but may act together in mixtures. Concentration-response curves of in vitro bioassays were often linear for effect levels 30%, and the predictions for concentration addition (CA) of similarly acting chemicals and for independent action (IA) of dissimilarly acting chemicals overlapped. We derived a joint CA/IA mixture model for the low-effect level portion of concentration-response curves. In a first case study, we evaluated the cytotoxicity of over 200 mixtures of up to 17 components that were mixed in concentration ratios as they occurred in river water. The predictions of the full IA model were indistinguishable from the predictions of the full CA model up to 10% effect, confirming the applicability of the joint CA/IA mixture model at low effect levels. In a second case study, we evaluated if environmental concentrations trigger effects at levels low enough for the joint CA/IA mixture model to apply. The detected concentrations were scaled by their toxic potencies to estimate the mixture effect of the detected chemicals in a complex mixture. In 86% of 156 samples the effects fell in the validity range of the joint CA/IA mixture model (10% effect level), confirming the CA assumption for toxic unit summation. The joint CA/IA mixture model is not suitable for testing specific mixture hypotheses and interactions of chemicals in mixtures, where more refined models are required; but it is helpful for the interpretation of effects of complex (multicomponent) environmental mixtures, especially for water samples with relatively low effect level.Environ Toxicol Chem2020;00:1-8. (c) 2020 The Authors.Environmental Toxicology and Chemistrypublished by Wiley Periodicals LLC on behalf of SETAC.
机译：发射到环境中的化学物质通常以低浓度存在，但可以在混合物中起作用。体外生物测定的浓度 - 反应曲线通常是线性的，用于效果水平<30％，以及类似作用化学品的浓度添加（CA）的预测，其不同作用化学品重叠的不同作用化学品。我们衍生一种用于浓度响应曲线的低效应水平部分的CA / IA混合物模型。在第一种案例研究中，我们评估了200多种多达17种组分的细胞毒性，其在河水中发生浓度比混合。完全IA模型的预测与完整CA型效果高达10％的预测中难以区分，确认关节Ca / IA混合物模型在低效应水平下的适用性。在第二种案例研究中，我们评估了环境浓度是否在足够低的水平下触发效果，以适用于CA / IA混合物模型。检测到的浓度由其有毒效力缩放，以估计检测到的化学物质在复杂的混合物中的混合物效应。在156个样品中的86％中，效果落入了Ca / Ia混合物模型（<10％效应水平）的有效范围内，确认了有毒单位求和的CA假设。联合Ca / Ia混合物模型不适用于测试混合物中的特定混合物假设和化学物质的相互作用，其中需要更精细的型号;但它有助于解释复合物（多组分）环境混合物的影响，特别是对于具有相对低效应水平的水样。紫罗兰毒素Chem20202022020202020; 00：1-8。 （c）2020作者。由于Wiley期刊LLC代表Setac的环境和化学毒理学和化学毒理学。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号