Exposure and Risk Assessment of Hg, Cd, As, Tl, Se, and Mo in Women of Reproductive Age Using Urinary Biomonitoring

Coscolla Clara; Sanchez Alfredo; Corpas-Burgos Francisca; Lopez Antonio; Perez Rosa; Kuligowski Julia; Vento Maximo; Yusa Vicent

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Exposure and Risk Assessment of Hg, Cd, As, Tl, Se, and Mo in Women of Reproductive Age Using Urinary Biomonitoring

机译：利用泌尿生物监唱的妇幼的HG，CD，AS，TL，SE和MO的接触和风险评估

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The present study analyzed the exposure and risk assessment of 4 toxic (Hg, Cd, As, Tl) and 2 essential (Se, Mo) elements in 119 Spanish women of reproductive age. The focus was on the elements for which risk-based benchmark, biomonitoring equivalents, or health-related human biomonitoring values have already been established. All elements presented frequencies of detection of 100% (greater than the limit of detection), except for Cd (99%). The 95th percentile concentrations were, for the toxic metals, 358.37 mu g/L (total As), 1.10 mu g/L (Cd), 0.41 mu g/L (Tl), and 3.03 mu g/L (total Hg) and, for the essential elements, 68.95 mu g/L (total Se) and 154.67 (Mo). We examined sociodemographic factors and dietary habits of women as predictors of urinary metal concentrations. Arsenic was positively associated with fish, shellfish, and canned fish consumption, whereas Mo was found to be associated with the consumption of cereals and pastry products. Maternal urine levels of As were negatively correlated with gestational age. In a risk-assessment context, hazard quotients (HQs) using the 95th percentile ranged from 0.08 (Tl) to 15.1 (urinary speciated As), with Cd presenting an HQ of 1.1 (95th percentile). None of the essential metals presented concentrations higher than their upper intake level; however, 3% of the mothers showed lower levels of Se than the estimated average requirement (EAR) biomonitoring equivalent, and 20% of the mothers were found to have lower levels of Mo than the EAR biomonitoring equivalent, suggesting a nutritionally inadequate diet. Environ Toxicol Chem 2021;00:1-14. (c) 2021 SETAC

机译：本研究分析了119种生殖年龄的119名西班牙女性的4种毒性（HG，CD，AS，TL）和2个必要（SE，MO）元素的暴露和风险评估。重点是已经建立了基于风险的基准，生物监测等同物或健康相关人体生物监测值的元素。除CD（99％）外，所有元素呈现频率为100％（大于检测限）。对于有毒金属，95百分位浓度为358.37μg/ l（总为），1.10μg/ L（CD），0.41μg/ L（TL）和3.03μg/ L（总Hg）和，对于基本要素，68.95μg/ l（总体）和154.67（MO）。我们认为女性的社会造影因素和饮食习惯作为泌尿金属浓度的预测因子。砷与鱼类，贝类和鱼类消费有关，而MO被发现与谷物和糕点产品的消耗有关。母体尿液水平与妊娠年龄的负面相关。在风险评估上下文中，使用第95百分位的危险版本（HQS）范围为0.08（TL）至15.1（尿表示为），CD呈现为1.1（95百分位数）。呈现高于其上部进气水平的浓度均未呈现;然而，3％的母亲表现出较低的SE水平，而不是估计的平均需求（耳）生物监测等同物，并且发现20％的母亲比耳朵生物监测等同物具有较低水平的Mo，这表明营养不足的饮食。环境毒素化学2021; 00：1-14。（c）2021 Setac

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《Environmental toxicology and chemistry》 |2021年第5期|1477-1490|共14页
作者
Coscolla Clara; Sanchez Alfredo; Corpas-Burgos Francisca; Lopez Antonio; Perez Rosa; Kuligowski Julia; Vento Maximo; Yusa Vicent;
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作者单位

Fdn Promot Hlth & Biomed Res Valencia Reg FISABIO Publ Hlth Valencia Spain;

Publ Hlth Lab Alicante Alicante Spain;

Fdn Promot Hlth & Biomed Res Valencia Reg FISABIO Publ Hlth Valencia Spain;

Fdn Promot Hlth & Biomed Res Valencia Reg FISABIO Publ Hlth Valencia Spain;

Fdn Promot Hlth & Biomed Res Valencia Reg FISABIO Publ Hlth Valencia Spain;

Hlth Res Inst La Fe Neonatal Res Unit Valencia Spain;

Univ & Polytech Hosp La Fe Neonatal Unit Valencia Spain;

Fdn Promot Hlth & Biomed Res Valencia Reg FISABIO Publ Hlth Valencia Spain|Publ Hlth Lab Valencia Valencia Spain|Univ Valencia Analyt Chem Dept Valencia Spain;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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关键词
Human biomonitoring; Mothers; Metals; Urine; Risk assessment;

机译：人类生物监测;母亲;金属;尿;风险评估;

Exposure and Risk Assessment of Hg, Cd, As, Tl, Se, and Mo in Women of Reproductive Age Using Urinary Biomonitoring

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